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• W2949147456 abstract "Connectivity-based parcellation of subcortical structures using diffusion tractography is now a common paradigm in neuroscience. These analyses often imply voxel-level specificity of connectivity, and the formation of compact, spatially coherent clusters is often taken as strong imaging-based evidence for anatomically distinct subnuclei in an individual. In this study, we demonstrate that internal structure in diffusion anisotropy is not necessary for a plausible parcellation to be obtained, by spatially permuting diffusion parameters within the thalami and repeating the parcellation. Moreover, we show that, in a winner-takes-all paradigm, most voxels receive the same label before and after this shuffling process—a finding that is stable across image acquisitions and tractography algorithms. We therefore suggest that such parcellations should be interpreted with caution." @default.
• W2949147456 created "2019-06-27" @default.
• W2949147456 creator A5019533089 @default.
• W2949147456 creator A5063310833 @default.
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• W2949147456 date "2019-10-01" @default.
• W2949147456 modified "2023-09-26" @default.
• W2949147456 title "Tractography-based parcellation does not provide strong evidence of anatomical organisation within the thalamus" @default.
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• W2949147456 doi "https://doi.org/10.1016/j.neuroimage.2019.06.019" @default.
• W2949147456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31185275" @default.
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