FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949165024> ?p ?o ?g. }

• W2949165024 abstract "Abstract Cells can sense and respond to mechanical signals over relatively long distances across fibrous extracellular matrices. Recently proposed models suggest that long-range force transmission can be attributed to the nonlinear elasticity or fibrous nature of collagen matrices, yet the mechanism whereby fibers align remains unknown. Moreover, cell shape and anisotropy of cellular contraction are not considered in existing models, although recent experiments have shown that they play crucial roles. Here, we explore all of the key factors that influence long-range force transmission in cell-populated collagen matrices: alignment of collagen fibers, responses to applied force, strain stiffening properties of the aligned fibers, aspect ratios of the cells, and the polarization of cellular contraction. A constitutive law accounting for mechanically-driven collagen fiber reorientation is proposed. We systematically investigate the range of collagen fiber alignment using both finite element simulations and analytical calculations. Our results show that tension-driven collagen fiber alignment plays a crucial role in force transmission. Small critical stretch for fiber alignment, large fiber stiffness and fiber strain-hardening behavior enable long-range interaction. Furthermore, the range of collagen fiber alignment for elliptical cells with polarized contraction is much larger than that for spherical cells with diagonal contraction. A phase diagram showing the range of force transmission as a function of cell shape and polarization and matrix properties is presented. Our results are in good agreement with recent experiments, and highlight the factors that influence long-range force transmission, in particular tension-driven alignment of fibers. Our work has important relevance to biological processes including development, cancer metastasis and wound healing, suggesting conditions whereby cells communicate over long distances." @default.
• W2949165024 created "2019-06-27" @default.
• W2949165024 creator A5004976391 @default.
• W2949165024 creator A5011906405 @default.
• W2949165024 creator A5031069096 @default.
• W2949165024 creator A5033918482 @default.
• W2949165024 creator A5045288947 @default.
• W2949165024 date "2016-04-13" @default.
• W2949165024 modified "2023-10-18" @default.
• W2949165024 title "Long Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers" @default.
• W2949165024 cites W1500831274 @default.
• W2949165024 cites W1588127651 @default.
• W2949165024 cites W1966871331 @default.
• W2949165024 cites W1967894955 @default.
• W2949165024 cites W1991248456 @default.
• W2949165024 cites W1993488903 @default.
• W2949165024 cites W2004751440 @default.
• W2949165024 cites W2005568183 @default.
• W2949165024 cites W2007485712 @default.
• W2949165024 cites W2008652184 @default.
• W2949165024 cites W2011983343 @default.
• W2949165024 cites W2023683612 @default.
• W2949165024 cites W2025003977 @default.
• W2949165024 cites W2030019694 @default.
• W2949165024 cites W2030541652 @default.
• W2949165024 cites W2036690926 @default.
• W2949165024 cites W2041678725 @default.
• W2949165024 cites W2041779667 @default.
• W2949165024 cites W2063167928 @default.
• W2949165024 cites W2067011858 @default.
• W2949165024 cites W2074462333 @default.
• W2949165024 cites W2081671199 @default.
• W2949165024 cites W2081720885 @default.
• W2949165024 cites W2098291603 @default.
• W2949165024 cites W2100303404 @default.
• W2949165024 cites W2101728107 @default.
• W2949165024 cites W2102079607 @default.
• W2949165024 cites W2103220507 @default.
• W2949165024 cites W2113138993 @default.
• W2949165024 cites W2115205179 @default.
• W2949165024 cites W2127108170 @default.
• W2949165024 cites W2133809313 @default.
• W2949165024 cites W2144066197 @default.
• W2949165024 cites W2144112984 @default.
• W2949165024 cites W2154577866 @default.
• W2949165024 cites W2154851379 @default.
• W2949165024 cites W2170320977 @default.
• W2949165024 doi "https://doi.org/10.1101/048579" @default.
• W2949165024 hasPublicationYear "2016" @default.
• W2949165024 type Work @default.
• W2949165024 sameAs 2949165024 @default.
• W2949165024 citedByCount "0" @default.
• W2949165024 crossrefType "posted-content" @default.
• W2949165024 hasAuthorship W2949165024A5004976391 @default.
• W2949165024 hasAuthorship W2949165024A5011906405 @default.
• W2949165024 hasAuthorship W2949165024A5031069096 @default.
• W2949165024 hasAuthorship W2949165024A5033918482 @default.
• W2949165024 hasAuthorship W2949165024A5045288947 @default.
• W2949165024 hasBestOaLocation W29491650241 @default.
• W2949165024 hasConcept C120665830 @default.
• W2949165024 hasConcept C121332964 @default.
• W2949165024 hasConcept C121854251 @default.
• W2949165024 hasConcept C12554922 @default.
• W2949165024 hasConcept C159985019 @default.
• W2949165024 hasConcept C185592680 @default.
• W2949165024 hasConcept C189165786 @default.
• W2949165024 hasConcept C192562407 @default.
• W2949165024 hasConcept C2779372316 @default.
• W2949165024 hasConcept C519885992 @default.
• W2949165024 hasConcept C55493867 @default.
• W2949165024 hasConcept C57879066 @default.
• W2949165024 hasConcept C85725439 @default.
• W2949165024 hasConcept C86803240 @default.
• W2949165024 hasConceptScore W2949165024C120665830 @default.
• W2949165024 hasConceptScore W2949165024C121332964 @default.
• W2949165024 hasConceptScore W2949165024C121854251 @default.
• W2949165024 hasConceptScore W2949165024C12554922 @default.
• W2949165024 hasConceptScore W2949165024C159985019 @default.
• W2949165024 hasConceptScore W2949165024C185592680 @default.
• W2949165024 hasConceptScore W2949165024C189165786 @default.
• W2949165024 hasConceptScore W2949165024C192562407 @default.
• W2949165024 hasConceptScore W2949165024C2779372316 @default.
• W2949165024 hasConceptScore W2949165024C519885992 @default.
• W2949165024 hasConceptScore W2949165024C55493867 @default.
• W2949165024 hasConceptScore W2949165024C57879066 @default.
• W2949165024 hasConceptScore W2949165024C85725439 @default.
• W2949165024 hasConceptScore W2949165024C86803240 @default.
• W2949165024 hasLocation W29491650241 @default.
• W2949165024 hasLocation W29491650242 @default.
• W2949165024 hasLocation W29491650243 @default.
• W2949165024 hasOpenAccess W2949165024 @default.
• W2949165024 hasPrimaryLocation W29491650241 @default.
• W2949165024 hasRelatedWork W1964373394 @default.
• W2949165024 hasRelatedWork W1973431600 @default.
• W2949165024 hasRelatedWork W1978694091 @default.
• W2949165024 hasRelatedWork W2032807528 @default.
• W2949165024 hasRelatedWork W2033100407 @default.
• W2949165024 hasRelatedWork W2044941839 @default.
• W2949165024 hasRelatedWork W2104121074 @default.
• W2949165024 hasRelatedWork W2152456342 @default.

• next