Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949180517> ?p ?o ?g. }
- W2949180517 abstract "Abstract Dendrites integrate inputs in highly non-linear ways, but it is unclear how these non-linearities contribute to the overall input-output transformation of single neurons. Here, we developed statistically principled methods using a hierarchical cascade of linear-nonlinear subunits (hLN) to model the dynamically evolving somatic response of neurons receiving complex spatio-temporal synaptic input patterns. We used the hLN to predict the membrane potential of a detailed biophysical model of a L2/3 pyramidal cell receiving in vivo -like synaptic input and reproducing in vivo dendritic recordings. We found that more than 90% of the somatic response could be captured by linear integration followed a single global non-linearity. Multiplexing inputs into parallel processing channels could improve prediction accuracy by as much as additional layers of local non-linearities. These results provide a data-driven characterisation of a key building block of cortical circuit computations: dendritic integration and the input-output transformation of single neurons during in vivo -like conditions." @default.
- W2949180517 created "2019-06-27" @default.
- W2949180517 creator A5007641436 @default.
- W2949180517 creator A5023602087 @default.
- W2949180517 creator A5090794040 @default.
- W2949180517 date "2017-12-16" @default.
- W2949180517 modified "2023-10-16" @default.
- W2949180517 title "Global, multiplexed dendritic computations under in vivo-like conditions" @default.
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