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- W2949197242 abstract "Streptococcus suis is a zoonotic pathogen that causes great economic losses to the swine industry and severe threats to public health. A better understanding of its physiology would contribute to the control of its infections. Although copper is an essential micronutrient for life, it is toxic to cells when present in excessive amounts. Herein, we provide evidence that CopA is required for S. suis resistance to copper toxicity. Quantitative PCR analysis showed that copA expression was specifically induced by copper. Growth curve analyses and spot dilution assays showed that the ΔcopA mutant was defective in media supplemented with elevated concentrations of copper. Spot dilution assays also revealed that CopA protected S. suis against the copper-induced bactericidal effect. Using inductively coupled plasma-optical emission spectroscopy, we demonstrated that the role of CopA in copper resistance was mediated by copper efflux. Collectively, our data indicated that CopA protects S. suis against the copper-induced bactericidal effect via copper efflux." @default.
- W2949197242 created "2019-06-27" @default.
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- W2949197242 date "2019-06-18" @default.
- W2949197242 modified "2023-09-27" @default.
- W2949197242 title "CopA Protects Streptococcus suis against Copper Toxicity" @default.
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- W2949197242 doi "https://doi.org/10.3390/ijms20122969" @default.
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