FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949202382> ?p ?o ?g. }

• W2949202382 endingPage "27422" @default.
• W2949202382 startingPage "27412" @default.
• W2949202382 abstract "// Zhe Liu 1, 3, * , Chao Yang 2, * , Xiangchun Li 2 , Wen Luo 2 , Bhaskar Roy 2 , Teng Xiong 2 , Xiuqing Zhang 2 , Huanming Yang 2, 4 , Jian Wang 2, 4 , Zhenhao Ye 5 , Yang Chen 5 , Jinghe Song 6 , Shuai Ma 6 , Yong Zhou 2 , Min Yang 1, 7 , Xiaodong Fang 2 and Jie Du 1 1 Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China 2 BGI Genomics, BGI-Shenzhen, Shenzhen, China 3 Beijing Advanced Innovation Center for Big Data and Brain Computing (BDBC), Beihang University, Beijing, China 4 James D. Watson Institute of Genome Sciences, Hangzhou, China 5 The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China 6 SKLSDE Lab, Beihang University, Beijing, China 7 State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China * These authors equally contribution to this work Correspondence to: Yong Zhou, email: zhouyong@bgi.com Min Yang, email: ymcq124@163.com Xiaodong Fang, email: fangxd@genomics.cn Jie Du, email: jdu@bcm.edu Keywords: colorectal cancer; whole-exome sequencing; disease etiology; Chinese patients; mutation spectrum Abbreviations: CRC: colorectal cancer; TCGA: the cancer genome atlas; SNV: single nucleotide variation; InDel: insertion and deletion Received: August 02, 2017      Accepted: March 06, 2018      Published: June 08, 2018 ABSTRACT Colorectal cancer is the fifth prevalent cancer in China. Nevertheless, a large-scale characterization of Chinese colorectal cancer mutation spectrum has not been carried out. In this study, we have performed whole exome-sequencing analysis of 98 patients’ tumor samples with matched pairs of normal colon tissues using Illumina and Complete Genomics high-throughput sequencing platforms. Canonical CRC somatic gene mutations with high prevalence (>10%) have been verified, including TP53 , APC , KRAS , SMAD4 , FBXW7 and PIK3CA . PEG3 is identified as a novel frequently mutated gene (10.6%). APC and Wnt signaling exhibit significantly lower mutation frequencies than those in TCGA data. Analysis with clinical characteristics indicates that APC gene and Wnt signaling display lower mutation rate in lymph node positive cancer than negative ones, which are not observed in TCGA data. APC gene and Wnt signaling are considered as the key molecule and pathway for colorectal cancer initiation, and these findings greatly undermine their importance in tumor progression for Chinese patients. Taken together, the application of next-generation sequencing has led to the determination of novel somatic mutations and alternative disease mechanisms in colorectal cancer progression, which may be useful for understanding disease mechanism and personalizing treatment for Chinese patients." @default.
• W2949202382 created "2019-06-27" @default.
• W2949202382 creator A5001522611 @default.
• W2949202382 creator A5004350071 @default.
• W2949202382 creator A5021496844 @default.
• W2949202382 creator A5024767151 @default.
• W2949202382 creator A5026484375 @default.
• W2949202382 creator A5028834004 @default.
• W2949202382 creator A5032764121 @default.
• W2949202382 creator A5049994616 @default.
• W2949202382 creator A5052083635 @default.
• W2949202382 creator A5053163511 @default.
• W2949202382 creator A5058814917 @default.
• W2949202382 creator A5066637324 @default.
• W2949202382 creator A5073326828 @default.
• W2949202382 creator A5073499085 @default.
• W2949202382 creator A5089829348 @default.
• W2949202382 creator A5090763809 @default.
• W2949202382 creator A5091161457 @default.
• W2949202382 date "2018-06-08" @default.
• W2949202382 modified "2023-10-17" @default.
• W2949202382 title "The landscape of somatic mutation in sporadic Chinese colorectal cancer" @default.
• W2949202382 cites W1969608756 @default.
• W2949202382 cites W1973950074 @default.
• W2949202382 cites W1986026469 @default.
• W2949202382 cites W1996181407 @default.
• W2949202382 cites W1999194714 @default.
• W2949202382 cites W2001258296 @default.
• W2949202382 cites W2009720434 @default.
• W2949202382 cites W2014332790 @default.
• W2949202382 cites W2022453199 @default.
• W2949202382 cites W2022495797 @default.
• W2949202382 cites W2025130792 @default.
• W2949202382 cites W2034054625 @default.
• W2949202382 cites W2040160664 @default.
• W2949202382 cites W2040289777 @default.
• W2949202382 cites W2044433401 @default.
• W2949202382 cites W2063228117 @default.
• W2949202382 cites W2066200716 @default.
• W2949202382 cites W2069114060 @default.
• W2949202382 cites W2083457841 @default.
• W2949202382 cites W2095692554 @default.
• W2949202382 cites W2103441770 @default.
• W2949202382 cites W2104195581 @default.
• W2949202382 cites W2105192488 @default.
• W2949202382 cites W2108234281 @default.
• W2949202382 cites W2119180969 @default.
• W2949202382 cites W2135020535 @default.
• W2949202382 cites W2136342095 @default.
• W2949202382 cites W2138601221 @default.
• W2949202382 cites W2142488410 @default.
• W2949202382 cites W2155659597 @default.
• W2949202382 cites W2159405409 @default.
• W2949202382 cites W2163235555 @default.
• W2949202382 cites W2262414037 @default.
• W2949202382 cites W2272984102 @default.
• W2949202382 cites W2291531085 @default.
• W2949202382 cites W2308791360 @default.
• W2949202382 cites W2339723519 @default.
• W2949202382 cites W2421455087 @default.
• W2949202382 cites W2463663094 @default.
• W2949202382 cites W2557187647 @default.
• W2949202382 cites W2561021019 @default.
• W2949202382 cites W2562820441 @default.
• W2949202382 cites W2563500544 @default.
• W2949202382 cites W2593413170 @default.
• W2949202382 cites W2594373254 @default.
• W2949202382 cites W2605738899 @default.
• W2949202382 cites W2618126900 @default.
• W2949202382 cites W4238448376 @default.
• W2949202382 doi "https://doi.org/10.18632/oncotarget.25287" @default.
• W2949202382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6007951" @default.
• W2949202382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29937994" @default.
• W2949202382 hasPublicationYear "2018" @default.
• W2949202382 type Work @default.
• W2949202382 sameAs 2949202382 @default.
• W2949202382 citedByCount "25" @default.
• W2949202382 countsByYear W29492023822019 @default.
• W2949202382 countsByYear W29492023822020 @default.
• W2949202382 countsByYear W29492023822021 @default.
• W2949202382 countsByYear W29492023822022 @default.
• W2949202382 countsByYear W29492023822023 @default.
• W2949202382 crossrefType "journal-article" @default.
• W2949202382 hasAuthorship W2949202382A5001522611 @default.
• W2949202382 hasAuthorship W2949202382A5004350071 @default.
• W2949202382 hasAuthorship W2949202382A5021496844 @default.
• W2949202382 hasAuthorship W2949202382A5024767151 @default.
• W2949202382 hasAuthorship W2949202382A5026484375 @default.
• W2949202382 hasAuthorship W2949202382A5028834004 @default.
• W2949202382 hasAuthorship W2949202382A5032764121 @default.
• W2949202382 hasAuthorship W2949202382A5049994616 @default.
• W2949202382 hasAuthorship W2949202382A5052083635 @default.
• W2949202382 hasAuthorship W2949202382A5053163511 @default.
• W2949202382 hasAuthorship W2949202382A5058814917 @default.
• W2949202382 hasAuthorship W2949202382A5066637324 @default.
• W2949202382 hasAuthorship W2949202382A5073326828 @default.
• W2949202382 hasAuthorship W2949202382A5073499085 @default.
• W2949202382 hasAuthorship W2949202382A5089829348 @default.

• next