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- W2949206784 abstract "The stiffness of the cardiovascular environment changes during ageing and in disease and contributes to disease incidence and progression. For instance, increased arterial stiffness can lead to atherosclerosis, while stiffening of the heart due to fibrosis can increase the chances of heart failure. Cells can sense the stiffness of the extracellular matrix through integrin adhesions and other mechanosensitive structures and in response to this initiate mechanosignalling pathways that ultimately change the cellular behaviour. Over the past decades, interest in mechanobiology has steadily increased and with this also our understanding of the molecular basis of mechanosensing and transduction. However, much of our knowledge about the mechanisms is derived from studies investigating focal adhesions in non-muscle cells, which are distinct in several regards from the cell–matrix adhesions in cardiomyocytes (costameres) or vascular smooth muscle cells (dense plaques or podosomes). Therefore, we will look here first at the evidence for mechanical sensing in the cardiovascular system, before comparing the different cytoskeletal arrangements and adhesion sites in cardiomyocytes and vascular smooth muscle cells and what is known about mechanical sensing through the various structures." @default.
- W2949206784 created "2019-06-27" @default.
- W2949206784 creator A5040341954 @default.
- W2949206784 creator A5045913952 @default.
- W2949206784 creator A5085179815 @default.
- W2949206784 date "2019-06-01" @default.
- W2949206784 modified "2023-10-15" @default.
- W2949206784 title "Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing" @default.
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