FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949206830> ?p ?o ?g. }

• W2949206830 abstract "Studies in genetic model organisms have revealed much about the development and pathology of complex tissues. Most have focused on cell-intrinsic gene functions and mechanisms. Much less is known about how transformed, or otherwise functionally disrupted, cells interact with healthy ones toward a favorable or pathological outcome. This is largely due to technical limitations. We developed new genetic tools in Drosophila melanogaster that permit efficient multiplexed gain- and loss-of-function genetic perturbations with separable spatial and temporal control. Importantly, our novel tool-set is independent of the commonly used GAL4/UAS system, freeing the latter for additional, non-autonomous, genetic manipulations; and is built into a single strain, allowing one-generation interrogation of non-autonomous effects. Altogether, our design opens up efficient genome-wide screens on any deleterious phenotype, once plasmid or genome engineering is used to place the desired miRNA(s) or ORF(s) into our genotype. Specifically, we developed tools to study extrinsic effects on neural tumor growth but the strategy presented has endless applications within and beyond neurobiology, and in other model organisms." @default.
• W2949206830 created "2019-06-27" @default.
• W2949206830 creator A5003834620 @default.
• W2949206830 creator A5008213136 @default.
• W2949206830 creator A5029571902 @default.
• W2949206830 creator A5066267826 @default.
• W2949206830 date "2018-11-27" @default.
• W2949206830 modified "2023-10-17" @default.
• W2949206830 title "Spatiotemporally controlled genetic perturbation for efficient large-scale studies of cell non-autonomous effects" @default.
• W2949206830 cites W1517500075 @default.
• W2949206830 cites W1520518044 @default.
• W2949206830 cites W1939684610 @default.
• W2949206830 cites W1967415231 @default.
• W2949206830 cites W1970731756 @default.
• W2949206830 cites W1974982857 @default.
• W2949206830 cites W1976557090 @default.
• W2949206830 cites W1981196392 @default.
• W2949206830 cites W1981336776 @default.
• W2949206830 cites W1981501084 @default.
• W2949206830 cites W1989244157 @default.
• W2949206830 cites W1990943845 @default.
• W2949206830 cites W1994772304 @default.
• W2949206830 cites W2004660622 @default.
• W2949206830 cites W2004868096 @default.
• W2949206830 cites W2006229889 @default.
• W2949206830 cites W2012674191 @default.
• W2949206830 cites W2018237142 @default.
• W2949206830 cites W2020543079 @default.
• W2949206830 cites W2021892293 @default.
• W2949206830 cites W2026175377 @default.
• W2949206830 cites W2027125425 @default.
• W2949206830 cites W2037611829 @default.
• W2949206830 cites W2051633630 @default.
• W2949206830 cites W2060089435 @default.
• W2949206830 cites W2060802334 @default.
• W2949206830 cites W2061140595 @default.
• W2949206830 cites W2081092282 @default.
• W2949206830 cites W2083455640 @default.
• W2949206830 cites W2091269769 @default.
• W2949206830 cites W2092900311 @default.
• W2949206830 cites W2098125485 @default.
• W2949206830 cites W2100247997 @default.
• W2949206830 cites W2110643873 @default.
• W2949206830 cites W2116824735 @default.
• W2949206830 cites W2123404816 @default.
• W2949206830 cites W2147055197 @default.
• W2949206830 cites W2149771940 @default.
• W2949206830 cites W2153401707 @default.
• W2949206830 cites W2157071511 @default.
• W2949206830 cites W2160777888 @default.
• W2949206830 cites W2166700927 @default.
• W2949206830 cites W2168230240 @default.
• W2949206830 cites W2339374701 @default.
• W2949206830 cites W2416819443 @default.
• W2949206830 cites W2487568192 @default.
• W2949206830 cites W2787402821 @default.
• W2949206830 cites W2792912544 @default.
• W2949206830 cites W3007599434 @default.
• W2949206830 doi "https://doi.org/10.7554/elife.38393" @default.
• W2949206830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6320068" @default.
• W2949206830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30479273" @default.
• W2949206830 hasPublicationYear "2018" @default.
• W2949206830 type Work @default.
• W2949206830 sameAs 2949206830 @default.
• W2949206830 citedByCount "0" @default.
• W2949206830 crossrefType "journal-article" @default.
• W2949206830 hasAuthorship W2949206830A5003834620 @default.
• W2949206830 hasAuthorship W2949206830A5008213136 @default.
• W2949206830 hasAuthorship W2949206830A5029571902 @default.
• W2949206830 hasAuthorship W2949206830A5066267826 @default.
• W2949206830 hasBestOaLocation W29492068301 @default.
• W2949206830 hasConcept C104317684 @default.
• W2949206830 hasConcept C127716648 @default.
• W2949206830 hasConcept C141231307 @default.
• W2949206830 hasConcept C19843653 @default.
• W2949206830 hasConcept C207177822 @default.
• W2949206830 hasConcept C2780104201 @default.
• W2949206830 hasConcept C54355233 @default.
• W2949206830 hasConcept C70721500 @default.
• W2949206830 hasConcept C86803240 @default.
• W2949206830 hasConceptScore W2949206830C104317684 @default.
• W2949206830 hasConceptScore W2949206830C127716648 @default.
• W2949206830 hasConceptScore W2949206830C141231307 @default.
• W2949206830 hasConceptScore W2949206830C19843653 @default.
• W2949206830 hasConceptScore W2949206830C207177822 @default.
• W2949206830 hasConceptScore W2949206830C2780104201 @default.
• W2949206830 hasConceptScore W2949206830C54355233 @default.
• W2949206830 hasConceptScore W2949206830C70721500 @default.
• W2949206830 hasConceptScore W2949206830C86803240 @default.
• W2949206830 hasFunder F4320319985 @default.
• W2949206830 hasLocation W29492068301 @default.
• W2949206830 hasLocation W29492068302 @default.
• W2949206830 hasLocation W29492068303 @default.
• W2949206830 hasLocation W29492068304 @default.
• W2949206830 hasLocation W29492068305 @default.
• W2949206830 hasLocation W29492068306 @default.
• W2949206830 hasOpenAccess W2949206830 @default.
• W2949206830 hasPrimaryLocation W29492068301 @default.
• W2949206830 hasRelatedWork W1009992280 @default.
• W2949206830 hasRelatedWork W2027125425 @default.

• next