Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949208852> ?p ?o ?g. }
- W2949208852 abstract "ZIKV reemerged in recent years, causing outbreaks in many parts of the world. Alarmingly, ZIKV infection has been associated with neurological complications such as Guillain-Barré syndrome (GBS) in adults and congenital fetal growth-associated anomalies in newborns. Host peripheral immune cells are one of the first to interact with the virus upon successful transmission from an infected female Aedes mosquito. However, little is known about the role of these immune cells during infection. In this work, the immune responses of monocytes, known target cells of ZIKV infection, were investigated by high-density transcriptomics. The analysis saw a robust immune response being elicited. Importantly, it also divulged that monocytes prime NK cell activities during virus infection. Removal of monocytes during the infection changed the immune milieu, which in turn reduced NK cell stimulation. This study provides valuable insights into the pathobiology of the virus and allows for the possibility of designing novel targeted therapeutics." @default.
- W2949208852 created "2019-06-27" @default.
- W2949208852 creator A5001021168 @default.
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- W2949208852 creator A5027937292 @default.
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- W2949208852 creator A5048188220 @default.
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- W2949208852 creator A5059648844 @default.
- W2949208852 creator A5065845915 @default.
- W2949208852 creator A5084874912 @default.
- W2949208852 creator A5090893993 @default.
- W2949208852 date "2018-04-25" @default.
- W2949208852 modified "2023-09-26" @default.
- W2949208852 title "Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity" @default.
- W2949208852 cites W1532141290 @default.
- W2949208852 cites W1545235721 @default.
- W2949208852 cites W1572255594 @default.
- W2949208852 cites W1620823095 @default.
- W2949208852 cites W1664824626 @default.
- W2949208852 cites W1693165432 @default.
- W2949208852 cites W1857453373 @default.
- W2949208852 cites W1905974666 @default.
- W2949208852 cites W1920308589 @default.
- W2949208852 cites W1923917571 @default.
- W2949208852 cites W1952587727 @default.
- W2949208852 cites W1965925125 @default.
- W2949208852 cites W1968308458 @default.
- W2949208852 cites W1970848783 @default.
- W2949208852 cites W1973619678 @default.
- W2949208852 cites W1975120587 @default.
- W2949208852 cites W1980134223 @default.
- W2949208852 cites W1994044627 @default.
- W2949208852 cites W1994347380 @default.
- W2949208852 cites W2000045275 @default.
- W2949208852 cites W2011751977 @default.
- W2949208852 cites W2015141049 @default.
- W2949208852 cites W2017041417 @default.
- W2949208852 cites W2017469817 @default.
- W2949208852 cites W2024834908 @default.
- W2949208852 cites W2026161448 @default.
- W2949208852 cites W2026721694 @default.
- W2949208852 cites W2051335877 @default.
- W2949208852 cites W2051568739 @default.
- W2949208852 cites W2055718337 @default.
- W2949208852 cites W2058593952 @default.
- W2949208852 cites W2067633711 @default.
- W2949208852 cites W2068556120 @default.
- W2949208852 cites W2077335256 @default.
- W2949208852 cites W2078399688 @default.
- W2949208852 cites W2081351941 @default.
- W2949208852 cites W2085385389 @default.
- W2949208852 cites W2085765334 @default.
- W2949208852 cites W2089573422 @default.
- W2949208852 cites W2096372976 @default.
- W2949208852 cites W2102156468 @default.
- W2949208852 cites W2104825199 @default.
- W2949208852 cites W2114104545 @default.
- W2949208852 cites W2115811695 @default.
- W2949208852 cites W2122449236 @default.
- W2949208852 cites W2128728003 @default.
- W2949208852 cites W2140729960 @default.
- W2949208852 cites W2143076511 @default.
- W2949208852 cites W2144619418 @default.
- W2949208852 cites W2145300964 @default.
- W2949208852 cites W2148989373 @default.
- W2949208852 cites W2151035991 @default.
- W2949208852 cites W2155444336 @default.
- W2949208852 cites W2160643757 @default.
- W2949208852 cites W2164596186 @default.
- W2949208852 cites W2168284316 @default.
- W2949208852 cites W2170551349 @default.
- W2949208852 cites W2171178051 @default.
- W2949208852 cites W2288486409 @default.
- W2949208852 cites W2292422784 @default.
- W2949208852 cites W2295245778 @default.
- W2949208852 cites W2320596818 @default.
- W2949208852 cites W2336153715 @default.
- W2949208852 cites W2347167903 @default.
- W2949208852 cites W2356757232 @default.
- W2949208852 cites W2400827254 @default.
- W2949208852 cites W2532259047 @default.
- W2949208852 cites W2577798709 @default.
- W2949208852 cites W2579523860 @default.
- W2949208852 cites W2584547672 @default.
- W2949208852 cites W2586352915 @default.
- W2949208852 cites W2589625654 @default.
- W2949208852 cites W2616211008 @default.
- W2949208852 cites W2617274523 @default.
- W2949208852 cites W2618918047 @default.
- W2949208852 cites W2624283321 @default.
- W2949208852 cites W2740763668 @default.
- W2949208852 cites W2748285847 @default.
- W2949208852 cites W2759977828 @default.