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- W2949216712 abstract "Modern sequencing machines produce order of a terabyte of data per day, which need subsequently to go through a complex processing pipeline. The conventional workflow begins with a few independent, shared-memory tools, which communicate by means of intermediate files. Given its lack of robustness and scalability, this approach is ill-suited to exploiting the full potential of sequencing in the context of healthcare, where large-scale, population-wide applications are the norm. In this work we propose the adoption of stream computing to simplify the genomic resequencing pipeline, boosting its performance and improving its fault-tolerance. We decompose the first steps of the genomic processing in two distinct and specialized modules (preprocessing and alignment) and we loosely compose them via communication through Kafka streams, in order to allow for easy composability and integration in the already-existing YARN-based pipelines. The proposed solution is then experimentally validated on real data and shown to scale almost linearly." @default.
- W2949216712 created "2019-06-27" @default.
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- W2949216712 date "2018-03-01" @default.
- W2949216712 modified "2023-10-18" @default.
- W2949216712 title "Kafka interfaces for composable streaming genomics pipelines" @default.
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- W2949216712 doi "https://doi.org/10.1109/bhi.2018.8333418" @default.
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