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- W2949251731 startingPage "2911" @default.
- W2949251731 abstract "In the past few decades, studies on translation have converged towards the metaphor of a “ribosome nanomachine”; they also revealed intriguing ribosome properties challenging this view. Many studies have shown that to perform an accurate protein synthesis in a fluctuating cellular environment, ribosomes sense, transfer information and even make decisions. This complex “behaviour” that goes far beyond the skills of a simple mechanical machine has suggested that the ribosomal protein networks could play a role equivalent to nervous circuits at a molecular scale to enable information transfer and processing during translation. We analyse here the significance of this analogy and establish a preliminary link between two fields: ribosome structure-function studies and the analysis of information processing systems. This cross-disciplinary analysis opens new perspectives about the mechanisms of information transfer and processing in ribosomes and may provide new conceptual frameworks for the understanding of the behaviours of unicellular organisms." @default.
- W2949251731 created "2019-06-27" @default.
- W2949251731 creator A5003787991 @default.
- W2949251731 creator A5041782714 @default.
- W2949251731 date "2019-06-14" @default.
- W2949251731 modified "2023-10-18" @default.
- W2949251731 title "Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives" @default.
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- W2949251731 doi "https://doi.org/10.3390/ijms20122911" @default.
- W2949251731 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6627100" @default.
- W2949251731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31207893" @default.
- W2949251731 hasPublicationYear "2019" @default.
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