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- W2949261036 abstract "Individual mRNAs are translated by multiple ribosomes that initiate translation with a few seconds interval. The ribosome speed is codon dependant, and ribosome queuing has been suggested to explain specific data for translation of some mRNAs in vivo. By modelling the stochastic translation process as a traffic problem, we here analyze conditions and consequences of collisions and queuing. The model allowed us to determine the on-rate (0.8 to 1.1 initiations per sec) and the time (1 sec) the preceding ribosome occludes initiation for Escherichia coli lacZ mRNA in vivo. We find that ribosome collisions and queues are inevitable consequences of a stochastic translation mechanism that reduce the translation efficiency substantially on natural mRNAs. The cells minimize collisions by having its mRNAs being unstable and by a highly selected codon usage in the start of the mRNA. The cost of mRNA breakdown is offset by the concomitant increase in translational efficiency." @default.
- W2949261036 created "2019-06-27" @default.
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- W2949261036 date "2008-09-25" @default.
- W2949261036 modified "2023-09-27" @default.
- W2949261036 title "Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization" @default.
- W2949261036 hasPublicationYear "2008" @default.
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