Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949263690> ?p ?o ?g. }
- W2949263690 abstract "Summary The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH can be accurately measured when informed by the molecular signatures of the normal cells of origin. We surveyed the transcriptomes of ∼ 4000 normal fallopian tube epithelial (FTE) cells, the cells of origin of serous ovarian cancer (SOC), and identified six FTE subtypes. We used subtype signatures to deconvolute SOC expression data and found substantial intra-tumor NGH that was previously unrecognized. Importantly, NGH-based stratification of ∼1700 tumors robustly predicted survival. Our findings lay the foundation for accurate prognostic and therapeutic stratification of SOC. Highlights The projection of FTE subtypes refines the molecular classification of serous OC Comprehensive single-cell profiling of FTE cells identifies 6 molecular subtypes Substantial non-genetic heterogeneity of HGSOC identified in 1700 tumors A mesenchymal-high HGSOC subtype is robustly correlated with poor prognosis" @default.
- W2949263690 created "2019-06-27" @default.
- W2949263690 creator A5000565081 @default.
- W2949263690 creator A5001438789 @default.
- W2949263690 creator A5006484532 @default.
- W2949263690 creator A5010390926 @default.
- W2949263690 creator A5017367163 @default.
- W2949263690 creator A5018056926 @default.
- W2949263690 creator A5021584004 @default.
- W2949263690 creator A5031856719 @default.
- W2949263690 creator A5032516438 @default.
- W2949263690 creator A5033229575 @default.
- W2949263690 creator A5037101147 @default.
- W2949263690 creator A5037552101 @default.
- W2949263690 creator A5053082429 @default.
- W2949263690 creator A5053512532 @default.
- W2949263690 creator A5056805446 @default.
- W2949263690 creator A5058098434 @default.
- W2949263690 creator A5063850993 @default.
- W2949263690 creator A5067125521 @default.
- W2949263690 creator A5071595533 @default.
- W2949263690 creator A5074772032 @default.
- W2949263690 creator A5084571119 @default.
- W2949263690 date "2019-06-17" @default.
- W2949263690 modified "2023-10-03" @default.
- W2949263690 title "The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells" @default.
- W2949263690 cites W1810028515 @default.
- W2949263690 cites W1916565700 @default.
- W2949263690 cites W1924525242 @default.
- W2949263690 cites W1938080407 @default.
- W2949263690 cites W1967304777 @default.
- W2949263690 cites W1976324983 @default.
- W2949263690 cites W1983482249 @default.
- W2949263690 cites W1985987855 @default.
- W2949263690 cites W1987012261 @default.
- W2949263690 cites W1992380352 @default.
- W2949263690 cites W1994699664 @default.
- W2949263690 cites W1996989652 @default.
- W2949263690 cites W1997338647 @default.
- W2949263690 cites W1998728654 @default.
- W2949263690 cites W2000684747 @default.
- W2949263690 cites W2003228990 @default.
- W2949263690 cites W2004256605 @default.
- W2949263690 cites W2008239810 @default.
- W2949263690 cites W2009980816 @default.
- W2949263690 cites W2013107316 @default.
- W2949263690 cites W2013462103 @default.
- W2949263690 cites W2015617213 @default.
- W2949263690 cites W2023316892 @default.
- W2949263690 cites W2023560061 @default.
- W2949263690 cites W2025669441 @default.
- W2949263690 cites W2026722048 @default.
- W2949263690 cites W2028593825 @default.
- W2949263690 cites W2028700197 @default.
- W2949263690 cites W2031263088 @default.
- W2949263690 cites W2036008499 @default.
- W2949263690 cites W2038963685 @default.
- W2949263690 cites W2040280971 @default.
- W2949263690 cites W2041783360 @default.
- W2949263690 cites W2045883614 @default.
- W2949263690 cites W2047763902 @default.
- W2949263690 cites W2060965924 @default.
- W2949263690 cites W2068767807 @default.
- W2949263690 cites W2069089843 @default.
- W2949263690 cites W2070058781 @default.
- W2949263690 cites W2071855640 @default.
- W2949263690 cites W2073302269 @default.
- W2949263690 cites W2079849392 @default.
- W2949263690 cites W2083548665 @default.
- W2949263690 cites W2083798214 @default.
- W2949263690 cites W2084863590 @default.
- W2949263690 cites W2089477889 @default.
- W2949263690 cites W2095927032 @default.
- W2949263690 cites W2098425296 @default.
- W2949263690 cites W2102619694 @default.
- W2949263690 cites W2104765303 @default.
- W2949263690 cites W2111282801 @default.
- W2949263690 cites W2117692326 @default.
- W2949263690 cites W2118667301 @default.
- W2949263690 cites W2119246219 @default.
- W2949263690 cites W2123696077 @default.
- W2949263690 cites W2129375080 @default.
- W2949263690 cites W2130458932 @default.
- W2949263690 cites W2131593373 @default.
- W2949263690 cites W2133465414 @default.
- W2949263690 cites W2136939537 @default.
- W2949263690 cites W2136962425 @default.
- W2949263690 cites W2137525633 @default.
- W2949263690 cites W2137526110 @default.
- W2949263690 cites W2138207763 @default.
- W2949263690 cites W2146512944 @default.
- W2949263690 cites W2150026213 @default.
- W2949263690 cites W2150791259 @default.
- W2949263690 cites W2158217645 @default.
- W2949263690 cites W2160938378 @default.
- W2949263690 cites W2160953558 @default.
- W2949263690 cites W2169895170 @default.
- W2949263690 cites W2171642372 @default.
- W2949263690 cites W2271458278 @default.
- W2949263690 cites W2272182458 @default.