Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949267777> ?p ?o ?g. }
- W2949267777 endingPage "e3000241" @default.
- W2949267777 startingPage "e3000241" @default.
- W2949267777 abstract "Centromeres are essential chromosomal regions that mediate kinetochore assembly and spindle attachments during cell division. Despite their functional conservation, centromeres are among the most rapidly evolving genomic regions and can shape karyotype evolution and speciation across taxa. Although significant progress has been made in identifying centromere-associated proteins, the highly repetitive centromeres of metazoans have been refractory to DNA sequencing and assembly, leaving large gaps in our understanding of their functional organization and evolution. Here, we identify the sequence composition and organization of the centromeres of Drosophila melanogaster by combining long-read sequencing, chromatin immunoprecipitation for the centromeric histone CENP-A, and high-resolution chromatin fiber imaging. Contrary to previous models that heralded satellite repeats as the major functional components, we demonstrate that functional centromeres form on islands of complex DNA sequences enriched in retroelements that are flanked by large arrays of satellite repeats. Each centromere displays distinct size and arrangement of its DNA elements but is similar in composition overall. We discover that a specific retroelement, G2/Jockey-3, is the most highly enriched sequence in CENP-A chromatin and is the only element shared among all centromeres. G2/Jockey-3 is also associated with CENP-A in the sister species D. simulans, revealing an unexpected conservation despite the reported turnover of centromeric satellite DNA. Our work reveals the DNA sequence identity of the active centromeres of a premier model organism and implicates retroelements as conserved features of centromeric DNA." @default.
- W2949267777 created "2019-06-27" @default.
- W2949267777 creator A5007700352 @default.
- W2949267777 creator A5025534876 @default.
- W2949267777 creator A5032112659 @default.
- W2949267777 creator A5035042211 @default.
- W2949267777 creator A5035740384 @default.
- W2949267777 creator A5041997172 @default.
- W2949267777 creator A5045366519 @default.
- W2949267777 creator A5057761009 @default.
- W2949267777 creator A5065699226 @default.
- W2949267777 creator A5068818676 @default.
- W2949267777 creator A5080307693 @default.
- W2949267777 creator A5085198820 @default.
- W2949267777 date "2019-05-14" @default.
- W2949267777 modified "2023-10-16" @default.
- W2949267777 title "Islands of retroelements are major components of Drosophila centromeres" @default.
- W2949267777 cites W1482190741 @default.
- W2949267777 cites W1492338945 @default.
- W2949267777 cites W1610193264 @default.
- W2949267777 cites W1822209018 @default.
- W2949267777 cites W1866460468 @default.
- W2949267777 cites W1943142958 @default.
- W2949267777 cites W1949152416 @default.
- W2949267777 cites W1973946233 @default.
- W2949267777 cites W1979827497 @default.
- W2949267777 cites W1982855075 @default.
- W2949267777 cites W1983272569 @default.
- W2949267777 cites W1995977745 @default.
- W2949267777 cites W2000659092 @default.
- W2949267777 cites W2002438422 @default.
- W2949267777 cites W2002878335 @default.
- W2949267777 cites W2003848087 @default.
- W2949267777 cites W2005270018 @default.
- W2949267777 cites W2006311225 @default.
- W2949267777 cites W2006635798 @default.
- W2949267777 cites W2009324132 @default.
- W2949267777 cites W2013939194 @default.
- W2949267777 cites W2014005472 @default.
- W2949267777 cites W2019005509 @default.
- W2949267777 cites W2019954887 @default.
- W2949267777 cites W2024960915 @default.
- W2949267777 cites W2026808496 @default.
- W2949267777 cites W2027101829 @default.
- W2949267777 cites W2031406887 @default.
- W2949267777 cites W2037607661 @default.
- W2949267777 cites W2038652554 @default.
- W2949267777 cites W2055043387 @default.
- W2949267777 cites W2056482755 @default.
- W2949267777 cites W2059907545 @default.
- W2949267777 cites W2060073273 @default.
- W2949267777 cites W2060945124 @default.
- W2949267777 cites W2067459265 @default.
- W2949267777 cites W2074468058 @default.
- W2949267777 cites W2095538203 @default.
- W2949267777 cites W2096128575 @default.
- W2949267777 cites W2096884102 @default.
- W2949267777 cites W2101071606 @default.
- W2949267777 cites W2102278945 @default.
- W2949267777 cites W2102613947 @default.
- W2949267777 cites W2102619694 @default.
- W2949267777 cites W2102904139 @default.
- W2949267777 cites W2103441770 @default.
- W2949267777 cites W2104141342 @default.
- W2949267777 cites W2106413052 @default.
- W2949267777 cites W2108234281 @default.
- W2949267777 cites W2108446493 @default.
- W2949267777 cites W2111628147 @default.
- W2949267777 cites W2112123846 @default.
- W2949267777 cites W2112814753 @default.
- W2949267777 cites W2114570899 @default.
- W2949267777 cites W2116279310 @default.
- W2949267777 cites W2116816847 @default.
- W2949267777 cites W2118826701 @default.
- W2949267777 cites W2119942722 @default.
- W2949267777 cites W2124514674 @default.
- W2949267777 cites W2125593645 @default.
- W2949267777 cites W2126837652 @default.
- W2949267777 cites W2127469308 @default.
- W2949267777 cites W2128880918 @default.
- W2949267777 cites W2132339860 @default.
- W2949267777 cites W2132510972 @default.
- W2949267777 cites W2133258435 @default.
- W2949267777 cites W2135007058 @default.
- W2949267777 cites W2136145671 @default.
- W2949267777 cites W2137683329 @default.
- W2949267777 cites W2140485761 @default.
- W2949267777 cites W2140516843 @default.
- W2949267777 cites W2141052558 @default.
- W2949267777 cites W2144454035 @default.
- W2949267777 cites W2148690960 @default.
- W2949267777 cites W2149915898 @default.
- W2949267777 cites W2151409320 @default.
- W2949267777 cites W2154180530 @default.
- W2949267777 cites W2157002105 @default.
- W2949267777 cites W2160248428 @default.
- W2949267777 cites W2160838716 @default.
- W2949267777 cites W2165893927 @default.