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- W2949271981 abstract "A novel type of compound that contains a peptide specific for bacterial peptidoglycans (immunomodulatory activity) and an adamantyl residue (antiviral activity) was synthesized. Thus, L-Ala-D-γGln was linked to DL-Gly(Ada) yielding two diasteroisomers 3a and 3b, i.e. ambo-Gly(Ada)-L-Ala-D-γGln (γGln = isoglutamine-4-amino-4-carbamoylbutanoic acid; Ada = adamantyl). The diastereoisomers were easily separated by column chromatography (silica gel) and characterized, but only the use of a stereospecific enzyme led to the assignment of the configuration of the Gly(Ada) moiety in the two diastereoisomers. The cytotoxic effect and antiviral activity of the novel adamantyltripeptides 3a and 3b, observed as the cell survival and the infectivity reduction of the influenza A virus H1N1 and H3N2 strains, respectively, were studied on MDCK cells in vitro. Both 3a and 3b exhibited low cytotoxicity for MDCK cells and reduced the infectivity of the influenza A virus strains, but to a different extent on different Strain." @default.
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- W2949271981 date "2010-08-19" @default.
- W2949271981 modified "2023-09-23" @default.
- W2949271981 title "ChemInform Abstract: Synthesis and Antiviral Activity of Novel Adamantylpeptides." @default.
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- W2949271981 doi "https://doi.org/10.1002/chin.199419233" @default.
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