Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949272649> ?p ?o ?g. }
- W2949272649 abstract "Summary Recent studies have uncovered thousands of long non-coding RNAs (IncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type-specific, and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this study, we investigated the function of β cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis. This revealed lncRNAs that function in concert with transcription factors to regulate β cell-specific transcriptional networks. We further demonstrate that lncRNA PLUTO affects local three-dimensional chromatin structure and transcription of PDX1, encoding a key β cell transcription factor, and that both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance. These results implicate lncRNAs in the regulation of β cell-specific transcription factor networks." @default.
- W2949272649 created "2019-06-27" @default.
- W2949272649 creator A5000803372 @default.
- W2949272649 creator A5001842615 @default.
- W2949272649 creator A5003297443 @default.
- W2949272649 creator A5005129014 @default.
- W2949272649 creator A5006759849 @default.
- W2949272649 creator A5008094462 @default.
- W2949272649 creator A5014654504 @default.
- W2949272649 creator A5020945167 @default.
- W2949272649 creator A5026332347 @default.
- W2949272649 creator A5026684297 @default.
- W2949272649 creator A5028692805 @default.
- W2949272649 creator A5047201441 @default.
- W2949272649 creator A5049656203 @default.
- W2949272649 creator A5057257184 @default.
- W2949272649 creator A5057958576 @default.
- W2949272649 creator A5063758669 @default.
- W2949272649 creator A5064387452 @default.
- W2949272649 creator A5067665792 @default.
- W2949272649 creator A5071946434 @default.
- W2949272649 creator A5074771810 @default.
- W2949272649 creator A5082048799 @default.
- W2949272649 creator A5084330205 @default.
- W2949272649 creator A5085077185 @default.
- W2949272649 creator A5087179037 @default.
- W2949272649 creator A5091231317 @default.
- W2949272649 date "2016-12-23" @default.
- W2949272649 modified "2023-10-18" @default.
- W2949272649 title "Human pancreatic β cell lncRNAs control cell-specific regulatory networks" @default.
- W2949272649 cites W1483760785 @default.
- W2949272649 cites W1830287761 @default.
- W2949272649 cites W1964789204 @default.
- W2949272649 cites W1964891375 @default.
- W2949272649 cites W1976804812 @default.
- W2949272649 cites W1981799113 @default.
- W2949272649 cites W1986234964 @default.
- W2949272649 cites W1995590588 @default.
- W2949272649 cites W1999746344 @default.
- W2949272649 cites W2000511325 @default.
- W2949272649 cites W2003553455 @default.
- W2949272649 cites W2005688198 @default.
- W2949272649 cites W2016048441 @default.
- W2949272649 cites W2016895073 @default.
- W2949272649 cites W2025393225 @default.
- W2949272649 cites W2027836023 @default.
- W2949272649 cites W2029919331 @default.
- W2949272649 cites W2030658020 @default.
- W2949272649 cites W2039278870 @default.
- W2949272649 cites W2044511756 @default.
- W2949272649 cites W2046097974 @default.
- W2949272649 cites W2047961180 @default.
- W2949272649 cites W2048056915 @default.
- W2949272649 cites W2050982262 @default.
- W2949272649 cites W2053293102 @default.
- W2949272649 cites W2055492712 @default.
- W2949272649 cites W2058601364 @default.
- W2949272649 cites W2065466457 @default.
- W2949272649 cites W2067674453 @default.
- W2949272649 cites W2071271349 @default.
- W2949272649 cites W2074656730 @default.
- W2949272649 cites W2078266900 @default.
- W2949272649 cites W2083794973 @default.
- W2949272649 cites W2084833542 @default.
- W2949272649 cites W2086392382 @default.
- W2949272649 cites W2092742937 @default.
- W2949272649 cites W2099468911 @default.
- W2949272649 cites W2100779682 @default.
- W2949272649 cites W2100982253 @default.
- W2949272649 cites W2105292164 @default.
- W2949272649 cites W2105349784 @default.
- W2949272649 cites W2112902148 @default.
- W2949272649 cites W2117165384 @default.
- W2949272649 cites W2119106393 @default.
- W2949272649 cites W2121626263 @default.
- W2949272649 cites W2126780067 @default.
- W2949272649 cites W2127576047 @default.
- W2949272649 cites W2128151873 @default.
- W2949272649 cites W2129078669 @default.
- W2949272649 cites W2137840425 @default.
- W2949272649 cites W2139458690 @default.
- W2949272649 cites W2141337702 @default.
- W2949272649 cites W2141831115 @default.
- W2949272649 cites W2144958072 @default.
- W2949272649 cites W2145372115 @default.
- W2949272649 cites W2146127531 @default.
- W2949272649 cites W2150098952 @default.
- W2949272649 cites W2156880688 @default.
- W2949272649 cites W2159615916 @default.
- W2949272649 cites W2160333540 @default.
- W2949272649 cites W2161413862 @default.
- W2949272649 cites W2162142896 @default.
- W2949272649 cites W2166967514 @default.
- W2949272649 cites W2194368213 @default.
- W2949272649 cites W4238656497 @default.
- W2949272649 cites W4378711309 @default.
- W2949272649 doi "https://doi.org/10.1101/096230" @default.
- W2949272649 hasPublicationYear "2016" @default.
- W2949272649 type Work @default.
- W2949272649 sameAs 2949272649 @default.