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- W2949273680 abstract "In order to maximize long-term rewards, agents must balance exploitation (choosing the option with the highest payoff) and exploration (gathering information about options that might have higher payoffs). Although the optimal solution to this trade-off is intractable, humans make use of two effective strategies: selectively exploring options with high uncertainty (directed exploration), and increasing the randomness of their choices when they are more uncertain (random exploration). Using a task that independently manipulates these two forms of exploration, we show that single nucleotide polymorphisms related to dopamine are associated with individual differences in exploration strategies. Variation in a gene linked to prefrontal dopamine (COMT) predicted the degree of directed exploration, as well as the overall randomness of responding. Variation in a gene linked to striatal dopamine (DARPP-32) predicted the degree of both directed and random exploration. These findings suggest that dopamine makes multiple contributions to exploration, depending on its afferent target." @default.
- W2949273680 created "2019-06-27" @default.
- W2949273680 creator A5018956214 @default.
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- W2949273680 date "2018-11-01" @default.
- W2949273680 modified "2023-10-15" @default.
- W2949273680 title "Dopaminergic genes are associated with both directed and random exploration" @default.
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- W2949273680 doi "https://doi.org/10.1016/j.neuropsychologia.2018.10.009" @default.
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