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- W2949274403 abstract "RNA half-life is closely related to its cellular physiological function, so stability determinants may have regulatory functions. Micro(mi)RNAs have primarily been studied with respect to post-transcriptional mRNA regulation and target degradation. Here we study the impact of the tumour suppressive melanoma miRNA miR-211 on transcriptome stability and phenotype in the non-pigmented melanoma cell line, A375. Using 5'-bromouridine IP chase (BRIC)-seq, transcriptome-wide RNA stability profiles revealed highly regulated genes and pathways important in this melanoma cell line. By combining BRIC-seq, RNA-seq and in silico predictions, we identified both existing and novel direct miR-211 targets. We validated DUSP3 as one such novel miR-211 target, which itself sustains colony formation and invasion in A375 cells via MAPK/PI3K signalling. miRNAs have the capacity to control RNA turnover as a gene expression mechanism, and RNA stability profiling is an excellent tool for interrogating functionally relevant gene regulatory pathways and miRNA targets when combined with other high-throughput and in silico approaches." @default.
- W2949274403 created "2019-06-27" @default.
- W2949274403 creator A5001711751 @default.
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- W2949274403 creator A5060115650 @default.
- W2949274403 creator A5076324927 @default.
- W2949274403 date "2019-06-16" @default.
- W2949274403 modified "2023-09-24" @default.
- W2949274403 title "Transcriptome stability profiling using 5’-bromouridine IP chase (BRIC-seq) identifies novel and functional microRNA targets in human melanoma cells" @default.
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- W2949274403 doi "https://doi.org/10.1080/15476286.2019.1629769" @default.
- W2949274403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6779404" @default.
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- W2949274403 hasPublicationYear "2019" @default.
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