Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949276682> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2949276682 endingPage "9168" @default.
- W2949276682 startingPage "9163" @default.
- W2949276682 abstract "Pyrimidine 1′-aza-C-nucleosides are synthesised by the fusion of 5-bromouracil, 5-bromocytosine and 5-bromoisocytosine with (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol in 40–41% yield. A homologue of 1′-aza-Ψ-uridine is obtained in a Mannich reaction in 65% yield by treatment of the azasugar, paraformaldehyde and uracil. N-Alkylation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol with 6-chloromethyluracil gives the 6-regioisomeric homologue. (3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol is synthesised in 25% overall yield from diacetone-d-glucose via 3-C-(azidomethyl)-3-deoxy-d-allose which is subjected to an intramolecular reductive amino alkylation reaction to give (3R,4S)-4-[(1S,2R)-1,2,3-trihydroxypropyl]pyrrolidin-3-ol followed by Fmoc protection, oxidative cleavage of the triol group with further reduction of the obtained aldehyde and subsequent deprotection of the nitrogen atom." @default.
- W2949276682 created "2019-06-27" @default.
- W2949276682 creator A5007455843 @default.
- W2949276682 creator A5011949236 @default.
- W2949276682 date "2001-10-01" @default.
- W2949276682 modified "2023-10-11" @default.
- W2949276682 title "Synthesis of 1′-aza-C-nucleosides from (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol" @default.
- W2949276682 cites W1506896046 @default.
- W2949276682 cites W1980977616 @default.
- W2949276682 cites W1984659682 @default.
- W2949276682 cites W2008523603 @default.
- W2949276682 cites W2021744027 @default.
- W2949276682 cites W2030268030 @default.
- W2949276682 cites W2047355774 @default.
- W2949276682 cites W2085601785 @default.
- W2949276682 cites W2116973836 @default.
- W2949276682 cites W2317765974 @default.
- W2949276682 cites W2333914755 @default.
- W2949276682 cites W2335170807 @default.
- W2949276682 cites W2950566854 @default.
- W2949276682 cites W2951034201 @default.
- W2949276682 cites W2951532343 @default.
- W2949276682 cites W2951561235 @default.
- W2949276682 cites W2952217680 @default.
- W2949276682 cites W4231998702 @default.
- W2949276682 doi "https://doi.org/10.1016/s0040-4020(01)00920-6" @default.
- W2949276682 hasPublicationYear "2001" @default.
- W2949276682 type Work @default.
- W2949276682 sameAs 2949276682 @default.
- W2949276682 citedByCount "22" @default.
- W2949276682 countsByYear W29492766822012 @default.
- W2949276682 countsByYear W29492766822013 @default.
- W2949276682 countsByYear W29492766822014 @default.
- W2949276682 countsByYear W29492766822015 @default.
- W2949276682 countsByYear W29492766822016 @default.
- W2949276682 countsByYear W29492766822020 @default.
- W2949276682 countsByYear W29492766822021 @default.
- W2949276682 crossrefType "journal-article" @default.
- W2949276682 hasAuthorship W2949276682A5007455843 @default.
- W2949276682 hasAuthorship W2949276682A5011949236 @default.
- W2949276682 hasConcept C134121241 @default.
- W2949276682 hasConcept C161790260 @default.
- W2949276682 hasConcept C164361826 @default.
- W2949276682 hasConcept C178790620 @default.
- W2949276682 hasConcept C185592680 @default.
- W2949276682 hasConcept C191897082 @default.
- W2949276682 hasConcept C192562407 @default.
- W2949276682 hasConcept C2778723968 @default.
- W2949276682 hasConcept C2779321679 @default.
- W2949276682 hasConcept C2779515768 @default.
- W2949276682 hasConcept C2779554091 @default.
- W2949276682 hasConcept C2779825165 @default.
- W2949276682 hasConcept C2779938440 @default.
- W2949276682 hasConcept C2780570554 @default.
- W2949276682 hasConcept C2780591741 @default.
- W2949276682 hasConcept C2781306241 @default.
- W2949276682 hasConcept C552990157 @default.
- W2949276682 hasConcept C55493867 @default.
- W2949276682 hasConcept C71240020 @default.
- W2949276682 hasConceptScore W2949276682C134121241 @default.
- W2949276682 hasConceptScore W2949276682C161790260 @default.
- W2949276682 hasConceptScore W2949276682C164361826 @default.
- W2949276682 hasConceptScore W2949276682C178790620 @default.
- W2949276682 hasConceptScore W2949276682C185592680 @default.
- W2949276682 hasConceptScore W2949276682C191897082 @default.
- W2949276682 hasConceptScore W2949276682C192562407 @default.
- W2949276682 hasConceptScore W2949276682C2778723968 @default.
- W2949276682 hasConceptScore W2949276682C2779321679 @default.
- W2949276682 hasConceptScore W2949276682C2779515768 @default.
- W2949276682 hasConceptScore W2949276682C2779554091 @default.
- W2949276682 hasConceptScore W2949276682C2779825165 @default.
- W2949276682 hasConceptScore W2949276682C2779938440 @default.
- W2949276682 hasConceptScore W2949276682C2780570554 @default.
- W2949276682 hasConceptScore W2949276682C2780591741 @default.
- W2949276682 hasConceptScore W2949276682C2781306241 @default.
- W2949276682 hasConceptScore W2949276682C552990157 @default.
- W2949276682 hasConceptScore W2949276682C55493867 @default.
- W2949276682 hasConceptScore W2949276682C71240020 @default.
- W2949276682 hasIssue "44" @default.
- W2949276682 hasLocation W29492766821 @default.
- W2949276682 hasOpenAccess W2949276682 @default.
- W2949276682 hasPrimaryLocation W29492766821 @default.
- W2949276682 hasRelatedWork W2014702888 @default.
- W2949276682 hasRelatedWork W2022582659 @default.
- W2949276682 hasRelatedWork W2084582310 @default.
- W2949276682 hasRelatedWork W2288084691 @default.
- W2949276682 hasRelatedWork W2339913352 @default.
- W2949276682 hasRelatedWork W2371436054 @default.
- W2949276682 hasRelatedWork W2383653237 @default.
- W2949276682 hasRelatedWork W2384310439 @default.
- W2949276682 hasRelatedWork W3061765863 @default.
- W2949276682 hasRelatedWork W4246047201 @default.
- W2949276682 hasVolume "57" @default.
- W2949276682 isParatext "false" @default.
- W2949276682 isRetracted "false" @default.
- W2949276682 magId "2949276682" @default.
- W2949276682 workType "article" @default.