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• W2949276938 abstract "Carboncarbon bond formation involving substitution of halogen by a carbon center represents undeniably the most common and important transformation in organic synthesis. In most cases, the selective introduction of an alkyl, allyl, benzyl, or propargyl chain in place of hydrogen atom at the carbon center of elaborated substrates has been achieved by generation of related organometallics and subsequent quenching with haloalkanes in a single operation. A high degree of stereocontrol can be reached. Several methods based on asymmetric deprotonation by chiral bases or on auxiliary controlled alkyl introduction have been reported and found to be particularly efficient. The enormous interest to catalytic asymmetric CC bond formation and the recent progresses in asymmetric enolate chemistry have been the focus of many applications in synthetic organic chemistry. In the context of this chapter, mainly based on the functionalization of tetrahedral carbons, discussions will be limited to C(sp3)–C(sp3) bond formation. Selected examples will be presented herein. The use of these metallation–substitution sequences in natural product and solid-phase synthesis are beyond the scope of this review. Coverage of structural studies and practical procedures will be kept to a minimum." @default.
• W2949276938 created "2019-06-27" @default.
• W2949276938 creator A5039649658 @default.
• W2949276938 creator A5082744174 @default.
• W2949276938 date "2005-01-01" @default.
• W2949276938 modified "2023-09-24" @default.
• W2949276938 title "One or More CC Bond(s) Formed by Substitution: Substitution of Halogen" @default.
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