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- W2949278713 abstract "Abstract We develop theory, based on earlier work, to partition heritability into a component due to a combination of parent of origin, maternal, paternal and shared environment, and another component that estimates classical additive genetic variance. We then investigate the effects on heritability of the parental origin of alleles in outbred heterogeneous stock rats across 199 complex traits. Parent-of-origin-like heritability was on average 2.7-fold larger than classical additive heritability. Among the phenotypes with the most enhanced parent-of-origin heritability were 10 coping style behaviors, with average 3.2-fold heritability enrichment. To confirm these findings on coping behaviour, and to eliminate the possibility that the parent of origin effects are due to confounding with shared environment, we performed a reciprocal F1 cross between the behaviourally divergent RHA and RLA rat strains. We observed parent-of-origin effects on F1 rat anxiety/coping-related behavior in the Elevated Zero Maze test. Our results are the first to assess genetic parent-of-origin effects in rats, and confirm earlier findings in mice that such effects influence mammalian coping and impulsive behavior." @default.
- W2949278713 created "2019-06-27" @default.
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- W2949278713 date "2018-06-20" @default.
- W2949278713 modified "2023-10-18" @default.
- W2949278713 title "Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat" @default.
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- W2949278713 doi "https://doi.org/10.1101/351155" @default.
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