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- W2949279002 abstract "The ability to control both the means and timing of sexual reproduction provides a powerful tool to understand not only fertilization but also life history trade-offs resulting from sexual reproduction. However, precisely controlling fertilization has proved a major challenge across model systems. An ideal sterility induction system should be external, non-toxic, and reversible. Using the auxin-inducible degradation system targeting the spe-44 gene within the nematode Caenorhabditis elegans, we designed a means of externally inducing spermatogenesis arrest. We show that exposure to auxin during larval development induces both hermaphrodite self-sterility and male sterility. Moreover, male sterility can be reversed upon cessation of auxin exposure. The sterility induction system developed here has multiple applications in the fields of spermatogenesis and mating systems evolution. Importantly, this system is also a highly applicable tool for aging studies. In particular, we show that auxin-induced self-sterility is comparable to the commonly used chemically-induced FUdR sterility, while offering multiple benefits, including being less labor intensive, being non-toxic, and avoiding compound interactions with other experimental treatments." @default.
- W2949279002 created "2019-06-27" @default.
- W2949279002 creator A5019884565 @default.
- W2949279002 creator A5030413677 @default.
- W2949279002 creator A5033185211 @default.
- W2949279002 date "2018-08-01" @default.
- W2949279002 modified "2023-10-18" @default.
- W2949279002 title "Auxin-Mediated Sterility Induction System for Longevity and Mating Studies in <i>Caenorhabditis elegans</i>" @default.
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- W2949279002 doi "https://doi.org/10.1534/g3.118.200278" @default.
- W2949279002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6071612" @default.
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