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- W2949294786 abstract "A straightforward, exact, precise and sensitive UV spectrophotometric assay technique and a basic and sensitive colorimetric assay method have been created and validated for the quantitative estimation of Ritonavir from bulk drug and tablet formulations. UV spectrophotometric strategy which includes the assurance of Ritonavir in bulk medication and pharmaceutical dosage forms and has an assimilation greatest at 240 nm in methanol. The Beer's law was obeyed over the concentration range of 10– 50µg/ml. The relationship coefficient was observed to be 0.9996 and it has demonstrated great linearity, reproducibility, accuracy in this fixation go. The % recuperation esteems were observed to be inside 98.76% - 99.73% demonstrated that the strategy was exact. The LOD and LOQ were observed to be 1.6µg/ml and 4.9µg/ml separately. The % RSD esteems were under 2. Colorimetric technique which includes the assurance of Ritonavir in mass medication and pharmaceutical dose frames. This method is based on the reaction of Ritonavir with 1 ml, 0.5% ferric chloride and 1ml, 0.2% potassium ferric cyanide to produce a bluish green colour, characteristic light absorption at 452 nm. The Beer’s law was obeyed over the concentration range of 20–100 µg/ml. The correlation coefficient was found to be 0.9997 and it has showed good linearity, reproducibility, precision in this concentration range. The % recovery values were found to be within 99.67–100.45% showed that the method was accurate. The LOD and LOQ were found to be 2.6 µg/ml and 7.9 µg/ml respectively. The % RSD values were less than 2. Keywords: Ritonavir, Potassium ferri cyanide, Ferric chloride, spectroscopy, method development, validation Cite this Article V. Devi Singh, G. Ashok, Taher Patel et al . Development and Validation of Spectrophotometric and Colorimetric Method for the Determination of Ritonavir in Its Bulk and Pharmaceutical Dosage Form. Trends in Drug Delivery . 2017; 4(3): 32–41p." @default.
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- W2949294786 date "2018-04-02" @default.
- W2949294786 modified "2023-09-25" @default.
- W2949294786 title "Development and Validation of Spectrophotometric and Colorimetric Method for the Determination of Ritonavir in its Bulk and Pharmaceutical Dosage Form" @default.
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