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• W2949304852 abstract "Mer-N5075A (1) and α-MAPI and β-MAPI (2 and 3) produced from a species of Streptomyces are new anomalous tetrapeptides having potential HIV-I protease inhibitory activity. The first total synthesis of 1 and a diastereomeric mixture of 2 and 3 was achieved simply by a route connecting two dipeptides. The synthetic method is applicable for synthesis of Mer-N5075A analogues, such as GE20372 A and B (4 and 5) and other chemically modified compounds. In addition, the inhibition of HIV-1 Protease and anti HIV activity by the compounds 1, a mixture of 2 and 3, and 24, 25, and 26 were described." @default.
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• W2949304852 date "2001-05-01" @default.
• W2949304852 modified "2023-10-09" @default.
• W2949304852 title "First total synthesis of Mer-N5075A and a diastereomeric mixture of α and β-MAPI, new HIV-I protease inhibitors from a species of Streptomyces" @default.
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• W2949304852 doi "https://doi.org/10.1016/s0040-4020(01)00323-4" @default.
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