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- W2949308002 abstract "The vital importance of the cell free layer (CFL) and wall shear stress (WSS) in microcirculation has given incentive to research to associate the blood flow behavior particularly in states of disease [1]. In this study, we introduce a new way to accurately calculate the WSS by simulations that employ a two-phase moving interface model, with the rich-in-RBCs core represented by the Quemada constitutive equation based on an existing theoretical approach of Shiram et al. [29]. Algebraic expressions for the cell free layer (CFL) and the wall shear stress are developed through simulations of blood flow in circular tubes with diameters ranging from 10 to 1000 μm and tube hematocrits from 25% to 55%. The results indicate a perfect agreement with experimental measurements compared to previous model predictions [2]. The imperative use of a more versatile model leads to the replacement of the two-phase flow with a single-phase model in combination with a wall slip condition tuned using the results of the initial, two-phase model. Consequently, the slip condition, which depends on both geometry and intrinsic hemorheological flow parameters, appropriately corrects the initial overestimation of WSS calculation (which in some cases reaches up to 60%) to eventually lead to realistic predictions for a microcirculation network. Conclusions for the efficiency of the slip condition are derived from the blood flow in more complex geometries and especially in a 2D transverse arteriolar bifurcation with cross sections being comparable to the red blood cells diameter. The assumption of blood as a continuous medium and the imposition of the slip rule which was derived from one-dimensional simulations reproduce the results of flow simulations that track individual blood cells. Performing a parametric analysis of significant hemorheological properties, it was found that the development of shear stress appreciably depends on the mass flow and the total flow rate fraction particularly for the segments near the bifurcation corners. The effectiveness of the slip law is also tested in a 3D bone marrow microvessel flow where the predictions for the average velocities at several sections of the geometry are compared with the experimental counterparts. Finally, investigation of blood flow in microcirculation and extraction of major hemodynamics laws are performed for microvessels while also accounting for the glycocalyx layer which lines the endothelial cells. Parametric analysis of the problem reveals a similar behavior of hemodynamics in microcirculation for microvessels with a diameter over 100 μm indicating the limit of the influence of the porous media layer adjacent to cell free layer." @default.
- W2949308002 created "2019-06-27" @default.
- W2949308002 creator A5069397987 @default.
- W2949308002 date "2017-10-20" @default.
- W2949308002 modified "2023-09-26" @default.
- W2949308002 title "Hemodynamics in microcirculation : a novel method for the accurate calculation of WSS" @default.
- W2949308002 hasPublicationYear "2017" @default.
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