FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949332565> ?p ?o ?g. }

• W2949332565 abstract "Guidelines recommend macrolides and fluoroquinolones in patients hospitalized with community-acquired pneumonia (CAP), but their use has been associated with cardiac events. We quantified associations between macrolide and fluoroquinolone use and cardiac events in patients hospitalized with CAP in non-ICU wards. This was a post-hoc analysis of a cluster-randomized trial as a cohort study; including patients with a working diagnosis of CAP admitted to non-ICU wards without a cardiac event on admission. We calculated cause-specific hazard ratio’s (HR’s) for effects of time-dependent macrolide and fluoroquinolone exposure as compared to beta-lactam monotherapy on cardiac events, defined as new or worsening heart failure, arrhythmia, or myocardial ischemia during hospitalization. Cardiac events occurred in 146 (6.9%) of 2107 patients, including heart failure (n = 101, 4.8%), arrhythmia (n = 53, 2.5%), and myocardial ischemia (n = 14, 0.7%). These occurred in 11 of 207 (5.3%), 18 of 250 (7.2%), and 31 of 277 (11.2%) patients exposed to azithromycin, clarithromycin, and erythromycin for at least one day, and in 9 of 234 (3.8%), 5 of 194 (2.6%), and 23 of 566 (4.1%) exposed to ciprofloxacin, levofloxacin, and moxifloxacin, respectively. HR’s for erythromycin, compared to beta-lactam monotherapy, on any cardiac event and heart failure were 1.60 (95% CI 1.09;2.36) and 1.89 (95% CI 1.22;2.91), respectively. HR’s for levofloxacin and moxifloxacin, compared to beta-lactam monotherapy, on any cardiac event were 0.40 (95% CI 0.18;0.87)and 0.56 (95% CI 0.36;0.87), respectively. Findings remained consistent after adjustment for confounders and/or in a sensitivity analysis of radiologically confirmed CAP (n = 1604, 76.1%). Among patients with CAP hospitalized to non-ICU wards, erythromycin use was associated with a 68% increased risk of hospital-acquired cardiac events, mainly heart failure. Levofloxacin and moxifloxacin were associated with a lower risk of heart failure. Although our study does not fully exclude confounding bias, findings remained largely unchanged in crude, adjusted, and sensitivity analyses. These findings may caution the use of erythromycin as empirical therapy in these patients. The original trial was retrospectively registered under ClinicalTrials.gov Identifier NCT01660204 on August 8th, 2012." @default.
• W2949332565 created "2019-06-27" @default.
• W2949332565 creator A5028086889 @default.
• W2949332565 creator A5030171913 @default.
• W2949332565 creator A5042743724 @default.
• W2949332565 creator A5046352757 @default.
• W2949332565 creator A5055970684 @default.
• W2949332565 creator A5073226069 @default.
• W2949332565 date "2019-01-07" @default.
• W2949332565 modified "2023-10-06" @default.
• W2949332565 title "Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial" @default.
• W2949332565 cites W1579434571 @default.
• W2949332565 cites W1977117900 @default.
• W2949332565 cites W1977884651 @default.
• W2949332565 cites W2019488451 @default.
• W2949332565 cites W2038981426 @default.
• W2949332565 cites W2046949207 @default.
• W2949332565 cites W2059378575 @default.
• W2949332565 cites W2064042720 @default.
• W2949332565 cites W2072217715 @default.
• W2949332565 cites W2107996101 @default.
• W2949332565 cites W2119425860 @default.
• W2949332565 cites W2133440505 @default.
• W2949332565 cites W2133979383 @default.
• W2949332565 cites W2147781714 @default.
• W2949332565 cites W2149554320 @default.
• W2949332565 cites W2150772812 @default.
• W2949332565 cites W2152733931 @default.
• W2949332565 cites W2154117702 @default.
• W2949332565 cites W2156718401 @default.
• W2949332565 cites W2158608977 @default.
• W2949332565 cites W2162469807 @default.
• W2949332565 cites W2164105341 @default.
• W2949332565 cites W2171284117 @default.
• W2949332565 cites W2616625093 @default.
• W2949332565 cites W2808237541 @default.
• W2949332565 cites W53712973 @default.
• W2949332565 cites W56436434 @default.
• W2949332565 doi "https://doi.org/10.1186/s12879-018-3630-7" @default.
• W2949332565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6322338" @default.
• W2949332565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30612559" @default.
• W2949332565 hasPublicationYear "2019" @default.
• W2949332565 type Work @default.
• W2949332565 sameAs 2949332565 @default.
• W2949332565 citedByCount "25" @default.
• W2949332565 countsByYear W29493325652019 @default.
• W2949332565 countsByYear W29493325652020 @default.
• W2949332565 countsByYear W29493325652021 @default.
• W2949332565 countsByYear W29493325652022 @default.
• W2949332565 countsByYear W29493325652023 @default.
• W2949332565 crossrefType "journal-article" @default.
• W2949332565 hasAuthorship W2949332565A5028086889 @default.
• W2949332565 hasAuthorship W2949332565A5030171913 @default.
• W2949332565 hasAuthorship W2949332565A5042743724 @default.
• W2949332565 hasAuthorship W2949332565A5046352757 @default.
• W2949332565 hasAuthorship W2949332565A5055970684 @default.
• W2949332565 hasAuthorship W2949332565A5073226069 @default.
• W2949332565 hasBestOaLocation W29493325651 @default.
• W2949332565 hasConcept C126322002 @default.
• W2949332565 hasConcept C164705383 @default.
• W2949332565 hasConcept C2776102371 @default.
• W2949332565 hasConcept C2776409635 @default.
• W2949332565 hasConcept C2776962512 @default.
• W2949332565 hasConcept C2777914695 @default.
• W2949332565 hasConcept C2778198053 @default.
• W2949332565 hasConcept C2778836808 @default.
• W2949332565 hasConcept C2778907293 @default.
• W2949332565 hasConcept C2781276175 @default.
• W2949332565 hasConcept C501593827 @default.
• W2949332565 hasConcept C71924100 @default.
• W2949332565 hasConcept C86803240 @default.
• W2949332565 hasConcept C89423630 @default.
• W2949332565 hasConceptScore W2949332565C126322002 @default.
• W2949332565 hasConceptScore W2949332565C164705383 @default.
• W2949332565 hasConceptScore W2949332565C2776102371 @default.
• W2949332565 hasConceptScore W2949332565C2776409635 @default.
• W2949332565 hasConceptScore W2949332565C2776962512 @default.
• W2949332565 hasConceptScore W2949332565C2777914695 @default.
• W2949332565 hasConceptScore W2949332565C2778198053 @default.
• W2949332565 hasConceptScore W2949332565C2778836808 @default.
• W2949332565 hasConceptScore W2949332565C2778907293 @default.
• W2949332565 hasConceptScore W2949332565C2781276175 @default.
• W2949332565 hasConceptScore W2949332565C501593827 @default.
• W2949332565 hasConceptScore W2949332565C71924100 @default.
• W2949332565 hasConceptScore W2949332565C86803240 @default.
• W2949332565 hasConceptScore W2949332565C89423630 @default.
• W2949332565 hasFunder F4320321007 @default.
• W2949332565 hasIssue "1" @default.
• W2949332565 hasLocation W29493325651 @default.
• W2949332565 hasLocation W29493325652 @default.
• W2949332565 hasLocation W29493325653 @default.
• W2949332565 hasLocation W29493325654 @default.
• W2949332565 hasLocation W29493325655 @default.
• W2949332565 hasLocation W29493325656 @default.
• W2949332565 hasLocation W29493325657 @default.
• W2949332565 hasOpenAccess W2949332565 @default.
• W2949332565 hasPrimaryLocation W29493325651 @default.
• W2949332565 hasRelatedWork W2023505524 @default.
• W2949332565 hasRelatedWork W2040639645 @default.
• W2949332565 hasRelatedWork W2075104600 @default.

• next