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• W2949332675 endingPage "8351" @default.
• W2949332675 startingPage "8329" @default.
• W2949332675 abstract "Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself." @default.
• W2949332675 created "2019-06-27" @default.
• W2949332675 creator A5055273994 @default.
• W2949332675 creator A5080191966 @default.
• W2949332675 date "2006-08-03" @default.
• W2949332675 modified "2023-10-01" @default.
• W2949332675 title "Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection" @default.
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