Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949346775> ?p ?o ?g. }
- W2949346775 abstract "Abstract Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1 , RBM20 , IRS2 , MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6 , SLAMF1 , APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association between obesity and insulin. Our study sheds light on the biological interactions between genetic variants driving differential methylation and gene expression in the early pathogenesis of T2D." @default.
- W2949346775 created "2019-06-27" @default.
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- W2949346775 date "2019-06-13" @default.
- W2949346775 modified "2023-10-18" @default.
- W2949346775 title "An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis" @default.
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