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- W2949380962 abstract "ABSTRACT Stress granules (SGs) are non-translating mRNP assemblies that form during stress. Herein, we use multiple smFISH probes for specific mRNAs to examine their SG recruitment and spatial organization. We observed that ribosome run-off is required for SG entry with long ORF mRNAs being delayed in SG accumulation, revealing SG transcriptome changes over time. Moreover, mRNAs are ~20X compacted from an expected linear length when translating and compact ~2 fold further in a stepwise manner beginning at the 5’ end during ribosome run-off. Surprisingly, the 5’ and 3’ ends of the examined mRNAs were separated in non-stress conditions, but in non-translating conditions, the ends of AHNAK and DYNC1H1 mRNAs become close, suggesting the closed-loop model of mRNPs preferentially forms on non-translating mRNAs. These results suggest translation inhibition triggers a mRNP reorganization that brings ends closer, which has implications for the regulation of mRNA stability and translation by 3’ UTR elements and the poly(A) tail." @default.
- W2949380962 created "2019-06-27" @default.
- W2949380962 creator A5014796446 @default.
- W2949380962 creator A5032768593 @default.
- W2949380962 date "2018-07-10" @default.
- W2949380962 modified "2023-10-18" @default.
- W2949380962 title "mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction" @default.
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- W2949380962 doi "https://doi.org/10.1101/366690" @default.
- W2949380962 hasPublicationYear "2018" @default.
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