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- W2949382039 abstract "Mammalian orthoreoviruses with reassortant genomes have recently been detected in various mammals and humans with respiratory, central nervous system, and gastrointestinal symptoms. This study describes the detection of the novel reassortant mammalian orthoreovirus SI-MRV07 in a traveler with gastroenteritis that returned from southeast Asia. The virus was initially detected with electron microscopy in stool, followed by propagation in the epithelial-like monkey kidney Marc145 cell line. Whole-genome sequencing revealed the reassortant nature of the genome segments, whereby the S1 genome segment was the most variable according to known sequences deposited in GenBank. Based on the nucleotide sequence of the S1 genome segment, the isolate clusters to serotype 2, close to the reference strain Jones T2J. The patient's serum showed the highest virus neutralization capacity toward SI-MRV07 and T2J isolates. This study provides additional insight into emerging mammalian orthoreoviruses with reassortant genomes and possible zoonotic potential, which should be carefully monitored in the future." @default.
- W2949382039 created "2019-06-27" @default.
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- W2949382039 date "2019-09-01" @default.
- W2949382039 modified "2023-09-24" @default.
- W2949382039 title "A novel reassortant mammalian orthoreovirus with a divergent S1 genome segment identified in a traveler with diarrhea" @default.
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- W2949382039 doi "https://doi.org/10.1016/j.meegid.2019.06.002" @default.
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