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- W2949392016 abstract "Cyclodextrins are extensively used in different fields (e.g., catalysis, chromatography, pharma, supramolecular chemistry, bioorganic chemistry, and bioinorganic chemistry), and their applications have been widely reviewed. Their main application in the field of pharmaceutical is as a drug carrier. This review overviews, for the first time, the use of cyclodextrins and their derivatives as antiaggregant agents in a number of proteins (e.g., amyloid-β, insulin, recombinant human growth hormone, prion protein, transthyretin, and α-synuclein) and some multimeric enzymes. There are many diseases that are correlated to protein misfolding and amyloid formation processes affecting numerous organs and tissues. There are over 30 different amyloid proteins and a number of corresponding diseases. Alzheimer's disease is the most common neurodegenerative disease. Treatment of these diseases is still a goal to reach, and many molecules are studied in this perspective. Cyclodextrins have also been studied, and they show great potential; as such, further studies could be very promising. This review aims to be a stimulus for the design of new cyclodextrin derivatives to obtain multifunctional systems with antiaggregant activity." @default.
- W2949392016 created "2019-06-27" @default.
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- W2949392016 creator A5041922182 @default.
- W2949392016 date "2016-07-01" @default.
- W2949392016 modified "2023-09-27" @default.
- W2949392016 title "ChemInform Abstract: Cyclodextrins as Protective Agents of Protein Aggregation: An Overview" @default.
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- W2949392016 doi "https://doi.org/10.1002/chin.201631271" @default.
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