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- W2949392034 abstract "Molecular tension sensors have contributed to a growing understanding of mechanobiology. However, the limited dynamic range and inability to specify the mechanical sensitivity of these sensors has hindered their widespread use in diverse contexts. Here, we systematically examine the components of tension sensors that can be altered to improve their functionality. Guided by the development of a first principles model describing the mechanical behavior of these sensors, we create a collection of sensors that exhibit predictable sensitivities and significantly improved performance in cellulo. Utilized in the context of vinculin mechanobiology, a trio of these new biosensors with distinct force- and extension-sensitivities reveal that an extension-based control paradigm regulates vinculin loading in a variety of mechanical contexts. To enable the rational design of molecular tension sensors appropriate for diverse applications, we predict the mechanical behavior, in terms of force and extension, of additional 1020 distinct designs." @default.
- W2949392034 created "2019-06-27" @default.
- W2949392034 creator A5017402732 @default.
- W2949392034 creator A5037332083 @default.
- W2949392034 creator A5090261482 @default.
- W2949392034 creator A5091364241 @default.
- W2949392034 date "2018-07-19" @default.
- W2949392034 modified "2023-10-17" @default.
- W2949392034 title "Tunable molecular tension sensors reveal extension-based control of vinculin loading" @default.
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- W2949392034 doi "https://doi.org/10.7554/elife.33927" @default.
- W2949392034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6053308" @default.
- W2949392034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30024378" @default.
- W2949392034 hasPublicationYear "2018" @default.
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