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• W2949397685 endingPage "414" @default.
• W2949397685 startingPage "414" @default.
• W2949397685 abstract "Hepatitis C virus (HCV) represents a major global health problem for which a vaccine is not available. Modified vaccinia virus Ankara (MVA)-HCV is a unique HCV vaccine candidate based in the modified vaccinia virus Ankara (MVA) vector expressing the nearly full-length genome of HCV genotype 1a that elicits CD8⁺ T-cell responses in mice. With the aim to improve the immune response of MVA-HCV and because of the importance of interferon (IFN) in HCV infection, we deleted in MVA-HCV the vaccinia virus (VACV) C6L gene, encoding an inhibitor of IFN-β that prevents activation of the interferon regulatory factors 3 and 7 (IRF3 and IRF7). The resulting vaccine candidate (MVA-HCV ΔC6L) expresses all HCV antigens and deletion of C6L had no effect on viral growth in permissive chicken cells. In human monocyte-derived dendritic cells, infection with MVA-HCV ΔC6L triggered severe down-regulation of IFN-β, IFN-β-induced genes, and cytokines in a manner similar to MVA-HCV, as defined by real-time polymerase chain reaction (PCR) and microarray analysis. In infected mice, both vectors had a similar profile of recruited immune cells and induced comparable levels of adaptive and memory HCV-specific CD8⁺ T-cells, mainly against p7 + NS2 and NS3 HCV proteins, with a T cell effector memory (TEM) phenotype. Furthermore, antibodies against E2 were also induced. Overall, our findings showed that while these vectors had a profound inhibitory effect on gene expression of the host, they strongly elicited CD8⁺ T cell and humoral responses against HCV antigens and to the virus vector. These observations add support to the consideration of these vectors as potential vaccine candidates against HCV." @default.
• W2949397685 created "2019-06-27" @default.
• W2949397685 creator A5007117539 @default.
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• W2949397685 date "2018-08-08" @default.
• W2949397685 modified "2023-10-05" @default.
• W2949397685 title "Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression" @default.
• W2949397685 cites W1562173282 @default.
• W2949397685 cites W1826210767 @default.
• W2949397685 cites W1967491261 @default.
• W2949397685 cites W1968426124 @default.
• W2949397685 cites W1969045843 @default.
• W2949397685 cites W1979003966 @default.
• W2949397685 cites W1989893709 @default.
• W2949397685 cites W1992465744 @default.
• W2949397685 cites W1996295206 @default.
• W2949397685 cites W1996383787 @default.
• W2949397685 cites W2001624137 @default.
• W2949397685 cites W2002914721 @default.
• W2949397685 cites W2005018860 @default.
• W2949397685 cites W2013092102 @default.
• W2949397685 cites W2013444425 @default.
• W2949397685 cites W2024364763 @default.
• W2949397685 cites W2028814295 @default.
• W2949397685 cites W2029717255 @default.
• W2949397685 cites W2035421116 @default.
• W2949397685 cites W2038281342 @default.
• W2949397685 cites W2043161692 @default.
• W2949397685 cites W2046714103 @default.
• W2949397685 cites W2046894540 @default.
• W2949397685 cites W2054690414 @default.
• W2949397685 cites W2056718686 @default.
• W2949397685 cites W2057292812 @default.
• W2949397685 cites W2058115636 @default.
• W2949397685 cites W2058283467 @default.
• W2949397685 cites W2072446271 @default.
• W2949397685 cites W2072859701 @default.
• W2949397685 cites W2073008794 @default.
• W2949397685 cites W2075973564 @default.
• W2949397685 cites W2076148928 @default.
• W2949397685 cites W2080667758 @default.
• W2949397685 cites W2081098333 @default.
• W2949397685 cites W2089326045 @default.
• W2949397685 cites W2092627204 @default.
• W2949397685 cites W2093579074 @default.
• W2949397685 cites W2107716585 @default.
• W2949397685 cites W2108362208 @default.
• W2949397685 cites W2124588431 @default.
• W2949397685 cites W2127548135 @default.
• W2949397685 cites W2128009173 @default.
• W2949397685 cites W2130259551 @default.
• W2949397685 cites W2135294077 @default.
• W2949397685 cites W2136218615 @default.
• W2949397685 cites W2137348686 @default.
• W2949397685 cites W2137766449 @default.
• W2949397685 cites W2137929296 @default.
• W2949397685 cites W2149903833 @default.
• W2949397685 cites W2151690631 @default.
• W2949397685 cites W2154524244 @default.
• W2949397685 cites W2157032531 @default.
• W2949397685 cites W2161293449 @default.
• W2949397685 cites W2165466482 @default.
• W2949397685 cites W2165852173 @default.
• W2949397685 cites W2172215633 @default.
• W2949397685 cites W2179871497 @default.
• W2949397685 cites W2200384624 @default.
• W2949397685 cites W2342248053 @default.
• W2949397685 cites W2405399426 @default.
• W2949397685 cites W2475269022 @default.
• W2949397685 cites W2504828590 @default.
• W2949397685 cites W2523365393 @default.
• W2949397685 cites W2531581876 @default.
• W2949397685 cites W2558439626 @default.
• W2949397685 cites W2605318304 @default.
• W2949397685 cites W2607429110 @default.
• W2949397685 cites W2620185115 @default.
• W2949397685 cites W2738895143 @default.
• W2949397685 cites W2763801778 @default.
• W2949397685 cites W2789260315 @default.
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• W2949397685 doi "https://doi.org/10.3390/v10080414" @default.
• W2949397685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6116028" @default.
• W2949397685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30096846" @default.
• W2949397685 hasPublicationYear "2018" @default.
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