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- W2949399496 abstract "Condensation of L- and D-3′-amino-2′,3′-dideoxynucleosides 2–5 with N-BOC-protected aminoacids 6 and 13 using dicyclohexylcarbodiimide and N-hydroxysuccinimide in DMF is reported to give the N-BOC-protected acylamino aminonucleosides 7–9 and 14 in 51–81% yield. After deprotection using trifluoroacetic acid the corresponding unprotected new analogues of puromucin 10–12 and 15 were obtained in 43–56% yield. These compounds did not show any significant antiviral activity using HIV (stain HTLV-III B)-infected MT-4 cells as target system." @default.
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- W2949399496 date "1992-01-01" @default.
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- W2949399496 title "Analogues of the antibiotic puromycin as potential prodrugs of 3′-amino-3′-deoxythymidine" @default.
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- W2949399496 doi "https://doi.org/10.1002/jhet.5570290102" @default.
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