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- W2949410316 abstract "Abstract According to the current World Health Organization (WHO) classification of central nervous system tumors, the definitive diagnosis of an oligodendroglioma WHO grade II or III depends on the presence of both a mutation of the gene encoding isocitrate dehydrogenase (IDH) and loss of heterozygosity on chromosomes 1p and 19q (LOH 1p/19q). This molecular signature characterizes a clinically relevant subgroup of gliomas in terms of epidemiology, clinical appearance, diagnostic evaluation, prognosis, and therapeutic recommendations. In this chapter, important aspects of open tumor surgery and stereotactic biopsy are critically discussed with regards to indication, surgical strategies, risk-benefit assessment, and outcome measurements. Practical considerations are provided in order to integrate the place of surgery into increasingly personalized management concepts for 1p/19q co-deleted oligodendrogliomas WHO grades II and III. For highly selected patients, interstitial brachytherapy is introduced as an alternative surgically performed treatment option." @default.
- W2949410316 created "2019-06-27" @default.
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- W2949410316 date "2019-01-01" @default.
- W2949410316 modified "2023-09-23" @default.
- W2949410316 title "Surgical management of 1p/19q co-deleted oligodendrogliomas WHO grade II and III" @default.
- W2949410316 doi "https://doi.org/10.1016/b978-0-12-813158-9.00018-9" @default.
- W2949410316 hasPublicationYear "2019" @default.
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