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• W2949410344 endingPage "100443" @default.
• W2949410344 startingPage "100443" @default.
• W2949410344 abstract "Abstract Background The correlation between rs1801133 variant of the MTHFR 1 gene and elevated homocysteine levels has been reported in diabetic nephropathy. High levels of homocysteine contribute to the progression and exacerbation of diabetes complications. Carnosine is a peptide that by antioxidant role can harness the toxic effect of homocysteine. In addition, the CNDP1 2 and CNDP2 3 genes are involved in the degradation of carnosine. The purpose of this study was to investigate the correlation between the rs2346061 (CNDP1), rs7577 (CNDP2), and rs1801133 (MTHFR) variants and diabetic nephropathy. Methods and materials In this study 310 individuals in three groups including Diabetic Nephropathy (DN) (n = 104), Type-2 Diabetes Mellitus without nephropathy (DM) (n = 100), and Healthy Control (HC) (n = 106) were recruited. The allele and genotype frequencies of rs2346061, rs7577 and rs1801133 were determined using PCR-RFLP technique. Results Mean serum homocysteine level was higher in patients with DN than individuals with DM. Plasma homocysteine level was positively associated with allele T of rs1801133 ( p p  > 0.05). There was no relationship between rs2346061 and rs7577 polymorphisms and homocysteine level. Conclusions These results confirmed the effect of the rs1801133 polymorphism on plasma homocysteine level in the HC group. No association was observed between rs2346061 and rs7577 and diabetic nephropathy in our patients ( p  > 0.05)." @default.
• W2949410344 created "2019-06-27" @default.
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• W2949410344 date "2019-09-01" @default.
• W2949410344 modified "2023-10-18" @default.
• W2949410344 title "Investigating the association of rs2346061 (CNDP1), rs7577 (CNDP2), and rs1801133 (MTHFR) variants and homocysteine level with diabetic nephropathy in an Iranian population" @default.
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• W2949410344 doi "https://doi.org/10.1016/j.genrep.2019.100443" @default.
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