Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949432513> ?p ?o ?g. }
- W2949432513 endingPage "1205" @default.
- W2949432513 startingPage "1195" @default.
- W2949432513 abstract "Abstract As a natural plant‐derived antitoxin, resveratrol possesses several pharmacological activities. This study aimed to evaluate the effects of resveratrol addition on nuclear maturation, oocyte quality during in vitro maturation (IVM) of porcine oocytes and subsequent early embryonic development following somatic cell nuclear transfer (SCNT). Our experiments showed that the treatment of porcine oocytes with 5 µM resveratrol during IVM resulted in the highest rate of the first polar body extrusion. Treatment of oocytes with resveratrol had no influence on cytoskeletal dynamics, whereas it significantly increased glucose uptake ability compared to the control oocytes. Oocytes matured with 5 μM resveratrol displayed significantly lower intracellular reactive oxygen species (ROS) levels and higher relative mRNA expression levels of the genes encoding such antioxidant enzymes as catalase ( CAT ) and superoxide dismutase 1 ( SOD1 ). In addition, resveratrol also prevented onset and progression of programmed cell death in porcine oocytes, which was confirmed by significant upregulation of the anti‐apoptotic B‐cell lymphoma 2 ( BCL‐2 ) gene and significant downregulation of the pro‐apoptotic BCL2‐associated X ( BAX ) gene. Furthermore, the blastocyst rates and the blastocyst cell numbers in cloned embryos derived from the oocytes that had matured in the presence of 5 μM resveratrol were significantly increased. In conclusion, supplementation of IVM medium with 5 μM resveratrol improves the quality of porcine oocytes by protecting them from oxidative damage and apoptosis, which leads to the production of meiotically matured oocytes exhibiting enhanced developmental potential following SCNT." @default.
- W2949432513 created "2019-06-27" @default.
- W2949432513 creator A5013705740 @default.
- W2949432513 creator A5021532810 @default.
- W2949432513 creator A5036613877 @default.
- W2949432513 creator A5044191015 @default.
- W2949432513 creator A5074231575 @default.
- W2949432513 creator A5082130351 @default.
- W2949432513 creator A5087044141 @default.
- W2949432513 date "2019-07-19" @default.
- W2949432513 modified "2023-10-16" @default.
- W2949432513 title "Effects of resveratrol on in vitro maturation of porcine oocytes and subsequent early embryonic development following somatic cell nuclear transfer" @default.
- W2949432513 cites W1432022173 @default.
- W2949432513 cites W1529934215 @default.
- W2949432513 cites W1963978740 @default.
- W2949432513 cites W1974943308 @default.
- W2949432513 cites W1987793536 @default.
- W2949432513 cites W1988945649 @default.
- W2949432513 cites W1990527421 @default.
- W2949432513 cites W1992780325 @default.
- W2949432513 cites W2009455793 @default.
- W2949432513 cites W2010765881 @default.
- W2949432513 cites W2011725492 @default.
- W2949432513 cites W2011827930 @default.
- W2949432513 cites W2011850946 @default.
- W2949432513 cites W2014425013 @default.
- W2949432513 cites W2016979866 @default.
- W2949432513 cites W2019573409 @default.
- W2949432513 cites W2023780628 @default.
- W2949432513 cites W2027543816 @default.
- W2949432513 cites W2028213259 @default.
- W2949432513 cites W2033746240 @default.
- W2949432513 cites W2038020917 @default.
- W2949432513 cites W2047224160 @default.
- W2949432513 cites W2049260203 @default.
- W2949432513 cites W2071388351 @default.
- W2949432513 cites W2073826591 @default.
- W2949432513 cites W2074017674 @default.
- W2949432513 cites W2077402273 @default.
- W2949432513 cites W2079509408 @default.
- W2949432513 cites W2083344678 @default.
- W2949432513 cites W2093311258 @default.
- W2949432513 cites W2094746916 @default.
- W2949432513 cites W2098627094 @default.
- W2949432513 cites W2105825262 @default.
- W2949432513 cites W2123016403 @default.
- W2949432513 cites W2132912180 @default.
- W2949432513 cites W2138612576 @default.
- W2949432513 cites W2149021404 @default.
- W2949432513 cites W2157819808 @default.
- W2949432513 cites W2160402200 @default.
- W2949432513 cites W2169999439 @default.
- W2949432513 cites W2172503623 @default.
- W2949432513 cites W2271857866 @default.
- W2949432513 cites W2341914727 @default.
- W2949432513 cites W2484159396 @default.
- W2949432513 cites W2521382863 @default.
- W2949432513 cites W2589469509 @default.
- W2949432513 cites W2606747134 @default.
- W2949432513 cites W2791278569 @default.
- W2949432513 cites W2802916870 @default.
- W2949432513 cites W2804179743 @default.
- W2949432513 cites W2886697337 @default.
- W2949432513 cites W2887368249 @default.
- W2949432513 cites W2893062013 @default.
- W2949432513 cites W2946366105 @default.
- W2949432513 cites W750310675 @default.
- W2949432513 cites W978230152 @default.
- W2949432513 doi "https://doi.org/10.1111/rda.13493" @default.
- W2949432513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31228864" @default.
- W2949432513 hasPublicationYear "2019" @default.
- W2949432513 type Work @default.
- W2949432513 sameAs 2949432513 @default.
- W2949432513 citedByCount "19" @default.
- W2949432513 countsByYear W29494325132020 @default.
- W2949432513 countsByYear W29494325132021 @default.
- W2949432513 countsByYear W29494325132022 @default.
- W2949432513 countsByYear W29494325132023 @default.
- W2949432513 crossrefType "journal-article" @default.
- W2949432513 hasAuthorship W2949432513A5013705740 @default.
- W2949432513 hasAuthorship W2949432513A5021532810 @default.
- W2949432513 hasAuthorship W2949432513A5036613877 @default.
- W2949432513 hasAuthorship W2949432513A5044191015 @default.
- W2949432513 hasAuthorship W2949432513A5074231575 @default.
- W2949432513 hasAuthorship W2949432513A5082130351 @default.
- W2949432513 hasAuthorship W2949432513A5087044141 @default.
- W2949432513 hasConcept C153911025 @default.
- W2949432513 hasConcept C16685009 @default.
- W2949432513 hasConcept C185592680 @default.
- W2949432513 hasConcept C196843134 @default.
- W2949432513 hasConcept C202438428 @default.
- W2949432513 hasConcept C2775838275 @default.
- W2949432513 hasConcept C2775966511 @default.
- W2949432513 hasConcept C2776108821 @default.
- W2949432513 hasConcept C2776151105 @default.
- W2949432513 hasConcept C2776690073 @default.
- W2949432513 hasConcept C2776816829 @default.
- W2949432513 hasConcept C2778177303 @default.