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- W2949451320 abstract "-Novel tricyclic heterocycle pyrimido[5,4-b]indolizine derivatives 1 were synthesized conveniently in two steps. The key intermediates 2-substituted 5-[(pyridin-2-yl)methyl]pyrimidin-4(3H)-ones 2 were obtained by facile cyclization of the acetate of Baylis-Hillman adduct 3 and various amidine hydrochlorides 4 in the presence of sodium ethoxide. Treatment of 5-[(pyridin-2-yl)methyl]pyrimidin-4(3H)-ones 2 with phosphoryl chloride by reflux afforded fused 2-substituted pyrimido[5,4-b]indolizines 1 in high yield." @default.
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- W2949451320 date "2008-01-01" @default.
- W2949451320 modified "2023-09-26" @default.
- W2949451320 title "Synthesis of 2-Substituted Pyrimido[5,4-b]indolizine Derivatives from Acetates of Baylis-Hillman Adducts" @default.
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- W2949451320 doi "https://doi.org/10.3987/com-08-11428" @default.
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