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- W2949451605 abstract "Background Obesity is over-represented in patients with psoriatic arthritis (PsA) and associated with increased disease activity. We have previously shown in 41 patients with PsA (Caspar criteria) and obesity (body mass index BMI ≥33 kg/m2) that weight loss treatment with Very Low Energy Liquid Diet (VLED), 640 kcal/day during 12-16 weeks, followed by a structured reintroduction of an energy restricted diet resulted in a median weight loss of 18.6% and concomitantly a significant improvement of the disease activity in joints, entheses and skin. At 6-months follow-up Psoriatic Arthritis Response Criteria (PsARC) was reached by 46.3% and American College of Rheumatology (ACR) 20, 50, 70 criteria for treatment response by 51.2%, 34.1% and 7.3% of the patients. Objectives To study the effects of the weight loss treatment on disease activity in longer term (12 months) in patients with PsA and obesity, when the patients are on a weight loss maintenance diet. Methods The patients were assessed with 66/68 joints count, Leeds enthesitis index, body surface area (BSA), questionnaires, CRP and BMI at the 12-months follow-up. Results Totally 39 PsA patients, median age 56 (IQR 49-63) years, 64% women were examined at the 12-month follow-up. The median weight reduction since baseline was 16.1 kg (IQR 10.5–22.8) or 16.0% (10.5–22.4). A majority of the disease activity parameters remained significantly improved (Table). At the 12-months follow-up PsARC was still fulfilled by 35.9% (n=14) and ACR 20, 50, 70 response criteria by 53.8% (n=21), 35.9% (n=14) and 15.5% (n=6) respectively. Conclusion Weight loss treatment with VLED in patients with PsA and obesity was associated with sustained weight reduction and lowered disease activity at 12-months follow-up. Disclosure of Interests Eva Klingberg Grant/research support from: Unrestricted grant from Roche, Consultant for: Novartis, Speakers bureau: Speakers fee from Lilly, Sofia Bjorkman: None declared, Bjorn Eliasson: None declared, Ingrid Larsson: None declared, Annelie Bilberg: None declared" @default.
- W2949451605 created "2019-06-27" @default.
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- W2949451605 date "2019-06-01" @default.
- W2949451605 modified "2023-09-25" @default.
- W2949451605 title "OP0008 SUSTAINED LOW DISEASE ACTIVITY AFTER WEIGHT LOSS TREATMENT IN PATIENTS WITH PSORIATIC ARTHRITIS AND OBESITY; A 12-MONTHS FOLLOW-UP" @default.
- W2949451605 doi "https://doi.org/10.1136/annrheumdis-2019-eular.5551" @default.
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