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- W2949458375 abstract "Abstract There is a pressing need to better understand the mechanisms underpinning the increasingly recognised non-motor deficits in Parkinson’s disease. Brain activity during Parkinson’s disease is excessively synchronized within the beta range (12–30Hz). However, relatively little is known about how the abnormal beta rhythms impact on non-motor symptoms. In healthy adults, beta desynchronization is necessary for successful episodic memory formation. We investigated whether there was a direct relationship between decreased beta modulation and memory formation in Parkinson’s disease. Electroencephalography recordings were made during an established memory-encoding paradigm. Parkinson’s participants showed impaired memory strength (P = 0.023) and reduced beta desynchronization (P = 0.014) relative to controls. Longer disease duration was correlated with a larger reduction in beta desynchronization, and a concomitant reduction in memory performance. These novel results extend the notion that pathological beta activity is causally implicated in the motor and (lesser appreciated) non-motor deficits inherent to Parkinson’s disease." @default.
- W2949458375 created "2019-06-27" @default.
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- W2949458375 date "2019-06-12" @default.
- W2949458375 modified "2023-09-27" @default.
- W2949458375 title "Impaired Desynchronization of Beta Activity Underlies Memory Deficits in People with Parkinson’s Disease" @default.
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- W2949458375 doi "https://doi.org/10.1101/667550" @default.
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