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• W2949489080 abstract "Cystic fibrosis (CF) is the most common fatal genetic disease affecting Canadian Caucasians. The majority of CF patients suffered from perpetual inflammation caused by Pseudomonas aeruginosa (P. aeruginosa). Previous, we found cells lacking functionalCFTR exhibit IL6 hypersecretion phenotype and a concomitant hyperactivity of p38 MAPK in response to P. aeruginosa. Therefore, I dedicated my master's thesis to investigate the link between increased IL6 production and p38 MAPK. ZC3H12A, an IL6-specific ribonuclease, was found to be a novel substrate of p38 MAPK and negatively regulated IL6 production from P. aeruginosa-stimulated airway epithelial cells. Together, these discoveries demonstrated a direct link between a specific signal transduction pathway and am RNA stability modulator, both of which contribute to the regulation of IL6 gene expression at a post-transcriptional level.%%%%La fibrose kystique (FK) est la maladie genetique mortelle la plus frequente parmi les canadiens d'origine caucasienne. La majorite des personnes atteintes souffrent d'une inflammation chronique causee par la bacterie Pseudomonas aeruginosa (P. aeruginosa). Precedemment, nous avons decouvert que des cellules depourvues de proteine CFTR fonctionnelle presentent un phenotype d'hypersecretion d'interleukin-6 et d'hyperactivite concomitante de la MAPK p38 en reponse a la bacterie. J'ai donc consacre ma maitrise a etudier le lien potentiel entre la MAPK p38 et la production elevee d'IL6. La ribonuclease ZC3H12A, specifique envers IL6, fut decouverte comme un nouveau substrat de la MAPK p38. Ces decouvertes ont demontre un lien direct entre une voie specifique de transduction du signal et un modulateur de stabilite de l'ARNm, les deux contribuant a la regulation post-transcriptionnelle de l'expression d'IL6." @default.
• W2949489080 created "2019-06-27" @default.
• W2949489080 creator A5024931596 @default.
• W2949489080 date "2011-01-01" @default.
• W2949489080 modified "2023-09-23" @default.
• W2949489080 title "The role of ZC3H12A in «Pseudomonas aeruginosa» infection of airway epithelial cells and implication in Cystic Fibrosis" @default.
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