Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949512677> ?p ?o ?g. }
- W2949512677 endingPage "9" @default.
- W2949512677 startingPage "1" @default.
- W2949512677 abstract "Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current progression of multi-kinase inhibitors and immunotherapies in the treatment of HCC. We highlight the mechanism underlying the ineffectiveness of these targeted therapies, including oncogenic alterations in driver genes and downstream pathways, high heterogeneity of HCC, and the mutual interaction of tumor microenvironment that promotes therapeutic resistance. We also discussed how these previous studies suggested for future therapeutic strategies. Besides, the complexity of HCC heterogeneity and cancer revolution need to be recognized in personalized therapy. Establishment of a drug screening system and identification of biomarkers of response is also in urgent need to overcome drug resistance. Meanwhile, a combination of targeted therapies could also be explored as a promising strategy in the future." @default.
- W2949512677 created "2019-06-27" @default.
- W2949512677 creator A5001206622 @default.
- W2949512677 creator A5001630552 @default.
- W2949512677 creator A5074288693 @default.
- W2949512677 creator A5080930329 @default.
- W2949512677 date "2019-09-01" @default.
- W2949512677 modified "2023-10-15" @default.
- W2949512677 title "Targeted therapy for hepatocellular carcinoma: Challenges and opportunities" @default.
- W2949512677 cites W1038682962 @default.
- W2949512677 cites W1487455823 @default.
- W2949512677 cites W1594929170 @default.
- W2949512677 cites W1828082159 @default.
- W2949512677 cites W1963590109 @default.
- W2949512677 cites W1963920328 @default.
- W2949512677 cites W1964321121 @default.
- W2949512677 cites W1964423256 @default.
- W2949512677 cites W1968209756 @default.
- W2949512677 cites W1971697388 @default.
- W2949512677 cites W1971837077 @default.
- W2949512677 cites W1975602357 @default.
- W2949512677 cites W1982488143 @default.
- W2949512677 cites W1994193851 @default.
- W2949512677 cites W1997769423 @default.
- W2949512677 cites W1998662458 @default.
- W2949512677 cites W2018851752 @default.
- W2949512677 cites W2019218097 @default.
- W2949512677 cites W2019294726 @default.
- W2949512677 cites W2036922484 @default.
- W2949512677 cites W2038047082 @default.
- W2949512677 cites W2046000826 @default.
- W2949512677 cites W2051684210 @default.
- W2949512677 cites W2056063027 @default.
- W2949512677 cites W2058388773 @default.
- W2949512677 cites W2067224679 @default.
- W2949512677 cites W2074189826 @default.
- W2949512677 cites W2079077102 @default.
- W2949512677 cites W2085002868 @default.
- W2949512677 cites W2094109552 @default.
- W2949512677 cites W2099477838 @default.
- W2949512677 cites W2105400883 @default.
- W2949512677 cites W2106285087 @default.
- W2949512677 cites W2107014272 @default.
- W2949512677 cites W2110643890 @default.
- W2949512677 cites W2111070218 @default.
- W2949512677 cites W2116159404 @default.
- W2949512677 cites W2116922255 @default.
- W2949512677 cites W2118796952 @default.
- W2949512677 cites W2119242310 @default.
- W2949512677 cites W2120967735 @default.
- W2949512677 cites W2123387119 @default.
- W2949512677 cites W2126908586 @default.
- W2949512677 cites W2128965737 @default.
- W2949512677 cites W2130011407 @default.
- W2949512677 cites W2132286877 @default.
- W2949512677 cites W2140446354 @default.
- W2949512677 cites W2140765540 @default.
- W2949512677 cites W2147834058 @default.
- W2949512677 cites W2148305615 @default.
- W2949512677 cites W2151600653 @default.
- W2949512677 cites W2158207366 @default.
- W2949512677 cites W2160834915 @default.
- W2949512677 cites W2164505583 @default.
- W2949512677 cites W2164938105 @default.
- W2949512677 cites W2168631000 @default.
- W2949512677 cites W2170513194 @default.
- W2949512677 cites W2175121570 @default.
- W2949512677 cites W2179055275 @default.
- W2949512677 cites W2198606871 @default.
- W2949512677 cites W2341498785 @default.
- W2949512677 cites W2346633916 @default.
- W2949512677 cites W2472847770 @default.
- W2949512677 cites W2507952693 @default.
- W2949512677 cites W2516498487 @default.
- W2949512677 cites W2528882804 @default.
- W2949512677 cites W2544609889 @default.
- W2949512677 cites W2548545914 @default.
- W2949512677 cites W2560154684 @default.
- W2949512677 cites W2560499218 @default.
- W2949512677 cites W2562740476 @default.
- W2949512677 cites W2567841939 @default.
- W2949512677 cites W2588118089 @default.
- W2949512677 cites W2598230851 @default.
- W2949512677 cites W2606367731 @default.
- W2949512677 cites W2625559053 @default.
- W2949512677 cites W2732904562 @default.
- W2949512677 cites W2736181072 @default.
- W2949512677 cites W2765565477 @default.
- W2949512677 cites W2765831845 @default.
- W2949512677 cites W2771057425 @default.
- W2949512677 cites W2779221466 @default.
- W2949512677 cites W2779948368 @default.
- W2949512677 cites W2787358630 @default.
- W2949512677 cites W2787553551 @default.
- W2949512677 cites W2791483720 @default.
- W2949512677 cites W2795488377 @default.
- W2949512677 cites W2796153225 @default.
- W2949512677 cites W2796153844 @default.