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- W2949532441 abstract "The synthesis and biological evaluation of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydro-naphtha len e (Z-1 and E-1) as nonsteroidal inhibitors of 17 alpha-hydroxylase-C17,20-lyase (P450 17, CYP 17) is described. Z-1 and E-1 were separated by column chromatography and identified by 1H NMR. The synthesis of the key compound 3 was accomplished by a new reaction acetylating the 1-methyl-6-methoxy-3,4-dihydronaphthalene compound 2 under Friedel-Crafts conditions. Compound 2 was obtained from the 1-tetralone via Wittig reaction. Using a microsomal fraction of human testicular enzyme, Z-1 and E-1 inhibited the target enzyme only marginally." @default.
- W2949532441 created "2019-06-27" @default.
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- W2949532441 date "2010-06-23" @default.
- W2949532441 modified "2023-09-25" @default.
- W2949532441 title "ChemInform Abstract: Synthesis of Z- and E-1-Methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and Evaluation as Inhibitors of 17α-Hydroxylase-C17,20-lyase (P450 17)." @default.
- W2949532441 cites W2078475877 @default.
- W2949532441 doi "https://doi.org/10.1002/chin.199809097" @default.
- W2949532441 hasPublicationYear "2010" @default.
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