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- W2949554565 abstract "ABSTRACT T cell activation by dendritic cells (DCs) involves forces exerted by the T cell actin cytoskeleton, which are opposed by the cortical cytoskeleton of the interacting APC. During an immune response, DCs undergo a maturation process that optimizes their ability to efficiently prime naïve T cells. Using atomic force microscopy, we find that during maturation, DC cortical stiffness increases via process that involves actin polymerization. Using stimulatory hydrogels and DCs expressing mutant cytoskeletal proteins, we find that increasing stiffness lowers the agonist dose needed for T cell activation. CD4 + T cells exhibit much more profound stiffness-dependency than CD8 + T cells. Finally, stiffness responses are most robust when T cells are stimulated with pMHC rather than anti-CD3ε, consistent with a mechanosensing mechanism involving receptor deformation. Taken together, our data reveal that maturation-associated cytoskeletal changes alter the biophysical properties of DCs, providing mechanical cues that costimulate T cell activation." @default.
- W2949554565 created "2019-06-27" @default.
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- W2949554565 date "2019-06-23" @default.
- W2949554565 modified "2023-10-11" @default.
- W2949554565 title "T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex" @default.
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- W2949554565 doi "https://doi.org/10.1101/680132" @default.
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