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- W2949565541 abstract "New sensitizers for photodynamic therapy were synthesized on the base of biologically generated chlorins and bacteriochlorins. Derivatives of chlorophyll a and bacteriochlorophyll were prepared from the biomass of blue-green algae Spirulina Platensis and purple bacteria Rhodobacter Capsulatus, generated using specially designed photobioreactor. The strategy for chemical transformation of natural chlorophylls and bacteriochlorophyll has been discussed. Purpurin 18 and its dihydroanalogue bacteriopurpurin were chosen as the key intermediates. Modifications of peripheral substituents, such as introducing the new functional groups, hydrogenation of the B-pyrrolic ring, and insertion of amino acid residues gave the series of novel sensitizers, including water soluble chlorin p6 analogues, and derivatives with graded amphiphility for the studies of tumor accumulation in the malignant tissues.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only." @default.
- W2949565541 created "2019-06-27" @default.
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- W2949565541 date "1996-01-08" @default.
- W2949565541 modified "2023-09-23" @default.
- W2949565541 title "<title>Second-generation photosensitizers based on natural chlorines and bacteriochlorines</title>" @default.
- W2949565541 doi "https://doi.org/10.1117/12.229483" @default.
- W2949565541 hasPublicationYear "1996" @default.
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