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• W2949573120 abstract "Large-scale biological networks represent relationships between genes, but our understanding of how networks are functionally organized is limited. Here, I describe spatial analysis of functional enrichment (SAFE), a systematic method for annotating biological networks and examining their functional organization. SAFE visualizes the network in 2D space and measures the continuous distribution of functional enrichment across local neighborhoods, producing a list of the associated functions and a map of their relative positioning. I applied SAFE to annotate the Saccharomyces cerevisiae genetic interaction similarity network and protein-protein interaction network with gene ontology terms. SAFE annotations of the genetic network matched manually derived annotations, while taking less than 1% of the time, and proved robust to noise and sensitive to biological signal. Integration of genetic interaction and chemical genomics data using SAFE revealed a link between vesicle-mediate transport and resistance to the anti-cancer drug bortezomib. These results demonstrate the utility of SAFE for examining biological networks and understanding their functional organization." @default.
• W2949573120 created "2019-06-27" @default.
• W2949573120 creator A5062354734 @default.
• W2949573120 date "2016-06-01" @default.
• W2949573120 modified "2023-10-13" @default.
• W2949573120 title "Systematic Functional Annotation and Visualization of Biological Networks" @default.
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• W2949573120 doi "https://doi.org/10.1016/j.cels.2016.04.014" @default.
• W2949573120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27237738" @default.
• W2949573120 hasPublicationYear "2016" @default.
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