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- W2949619058 abstract "This micro review focuses on the application of the modified Pictet-Spengler reaction to the synthesis of diverse polyheterocycles with structural resemblance to natural products. The modified Pictet-Spengler reaction takes use of tethered biheterocycles comprising nucleophilic partner and a source for electrophilic partner followed by their condensation with aldehydes/ketones to furnish annulated polyheterocycles. Using this strategy engineering of numerous tethered biheterocycles into annulated polyheterocycles has been successfully carried out using both 6-endo as well as 7-endo cyclizations. Keywords: Pictet-Spengler reaction, 6-endo cyclization, 7-endo cyclization, Polyheterocycles" @default.
- W2949619058 created "2019-06-27" @default.
- W2949619058 creator A5020244569 @default.
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- W2949619058 creator A5084627594 @default.
- W2949619058 creator A5085322386 @default.
- W2949619058 date "2012-05-01" @default.
- W2949619058 modified "2023-10-02" @default.
- W2949619058 title "Pictet-Spengler Reaction Revisited: Engineering of Tetherd Biheterocycles into Annulated Polyheterocycles" @default.
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- W2949619058 doi "https://doi.org/10.2174/157017912801270559" @default.
- W2949619058 hasPublicationYear "2012" @default.
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