FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949621837> ?p ?o ?g. }

• W2949621837 abstract "c-Kit, a type III receptor tyrosine kinase (RTK), is involved in multiple intracellular signaling whereby it is mainly considered a stem cell factor receptor, which participates in vital functions of the mammalian body, including the human. Furthermore, c-kit is a necessary yet not sufficient marker to detect and isolate several types of tissue-specific adult stem cells. Accordingly, c-kit was initially used as a marker to identify and enrich for adult cardiac stem/progenitor cells (CSCs) that were proven to be clonogenic, self-renewing and multipotent, being able to differentiate into cardiomyocytes, endothelial cells and smooth muscle cells in vitro as well as in vivo after myocardial injury. Afterwards it was demonstrated that c-kit expression labels a heterogenous cardiac cell population, which is mainly composed by endothelial cells while only a very small fraction represents CSCs. Furthermore, c-kit as a signaling molecule is expressed at different levels in this heterogenous c-kit labeled cardiac cell pool, whereby c-kit low expressers are enriched for CSCs while c-kit high expressers are endothelial and mast cells. This heterogeneity in cell composition and expression levels has been neglected in recent genetic fate map studies focusing on c-kit, which have claimed that c-kit identifies cells with robust endothelial differentiation potential but with minimal if not negligible myogenic commitment potential. However, modification of c-kit gene for Cre Recombinase expression in these Cre/Lox genetic fate map mouse models produced a detrimental c-kit haploinsufficiency that prevents efficient labeling of true CSCs on one hand while affecting the regenerative potential of these cells on the other. Interestingly, c-kit haploinsufficiency in c-kit-deficient mice causes a worsening myocardial repair after injury and accelerates cardiac aging. Therefore, these studies have further demonstrated that adult c-kit-labeled CSCs are robustly myogenic and that the adult myocardium relies on c-kit expression to regenerate after injury and to counteract aging effects on cardiac structure and function." @default.
• W2949621837 created "2019-06-27" @default.
• W2949621837 creator A5006053315 @default.
• W2949621837 creator A5020233680 @default.
• W2949621837 creator A5025808462 @default.
• W2949621837 creator A5028881457 @default.
• W2949621837 creator A5038662360 @default.
• W2949621837 creator A5046040897 @default.
• W2949621837 creator A5057681885 @default.
• W2949621837 creator A5063747611 @default.
• W2949621837 creator A5072326352 @default.
• W2949621837 creator A5077030565 @default.
• W2949621837 creator A5077265250 @default.
• W2949621837 date "2019-06-19" @default.
• W2949621837 modified "2023-09-30" @default.
• W2949621837 title "Role of c-Kit in Myocardial Regeneration and Aging" @default.
• W2949621837 cites W101749175 @default.
• W2949621837 cites W1264786469 @default.
• W2949621837 cites W1503914182 @default.
• W2949621837 cites W1523950660 @default.
• W2949621837 cites W1542955217 @default.
• W2949621837 cites W1586893565 @default.
• W2949621837 cites W1669479280 @default.
• W2949621837 cites W1869970828 @default.
• W2949621837 cites W1923017003 @default.
• W2949621837 cites W1965979634 @default.
• W2949621837 cites W1967335040 @default.
• W2949621837 cites W1969038150 @default.
• W2949621837 cites W1971858639 @default.
• W2949621837 cites W1972736348 @default.
• W2949621837 cites W1977025496 @default.
• W2949621837 cites W1978017776 @default.
• W2949621837 cites W1981522023 @default.
• W2949621837 cites W1981761127 @default.
• W2949621837 cites W1986821244 @default.
• W2949621837 cites W1988451304 @default.
• W2949621837 cites W1988821060 @default.
• W2949621837 cites W1991175004 @default.
• W2949621837 cites W1993932646 @default.
• W2949621837 cites W1995049749 @default.
• W2949621837 cites W1997195556 @default.
• W2949621837 cites W2000519963 @default.
• W2949621837 cites W2001219281 @default.
• W2949621837 cites W2008016893 @default.
• W2949621837 cites W2009527263 @default.
• W2949621837 cites W2010368308 @default.
• W2949621837 cites W2013158299 @default.
• W2949621837 cites W2019562841 @default.
• W2949621837 cites W2020857408 @default.
• W2949621837 cites W2025804021 @default.
• W2949621837 cites W2027134089 @default.
• W2949621837 cites W2028036560 @default.
• W2949621837 cites W2032211438 @default.
• W2949621837 cites W2037695813 @default.
• W2949621837 cites W2041119309 @default.
• W2949621837 cites W2041668737 @default.
• W2949621837 cites W2042041738 @default.
• W2949621837 cites W2046027917 @default.
• W2949621837 cites W2049314578 @default.
• W2949621837 cites W2050561917 @default.
• W2949621837 cites W2054604628 @default.
• W2949621837 cites W2055323054 @default.
• W2949621837 cites W2056359927 @default.
• W2949621837 cites W2058446860 @default.
• W2949621837 cites W2059984016 @default.
• W2949621837 cites W2061170693 @default.
• W2949621837 cites W2061991201 @default.
• W2949621837 cites W2063436204 @default.
• W2949621837 cites W2063705496 @default.
• W2949621837 cites W2065171831 @default.
• W2949621837 cites W2067009965 @default.
• W2949621837 cites W2070431417 @default.
• W2949621837 cites W2070772918 @default.
• W2949621837 cites W2071841171 @default.
• W2949621837 cites W2072004228 @default.
• W2949621837 cites W2074431288 @default.
• W2949621837 cites W2075401648 @default.
• W2949621837 cites W2076837609 @default.
• W2949621837 cites W2078281649 @default.
• W2949621837 cites W2078443370 @default.
• W2949621837 cites W2084055979 @default.
• W2949621837 cites W2084600834 @default.
• W2949621837 cites W2086493260 @default.
• W2949621837 cites W2086941834 @default.
• W2949621837 cites W2088513836 @default.
• W2949621837 cites W2093494581 @default.
• W2949621837 cites W2095059099 @default.
• W2949621837 cites W2096391100 @default.
• W2949621837 cites W2098590189 @default.
• W2949621837 cites W2099821071 @default.
• W2949621837 cites W2101986300 @default.
• W2949621837 cites W2102934400 @default.
• W2949621837 cites W2103054294 @default.
• W2949621837 cites W2103637156 @default.
• W2949621837 cites W2104206289 @default.
• W2949621837 cites W2105241495 @default.
• W2949621837 cites W2105956218 @default.
• W2949621837 cites W2110275581 @default.
• W2949621837 cites W2112173990 @default.
• W2949621837 cites W2113074426 @default.

• next