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- W2949628298 abstract "Abstract Changes of nuclear localization of lineage‐specific genes from a transcriptionally inert to permissive environment are a crucial step in establishing the identity of a cell. Noncoding RNA transcription‐mediated genome folding and activation of target gene expression have been found in a variety of cell types. Noncoding RNA ThymoD (thymocyte differentiation factor) transcription at superenhancers is essential for mouse T‐cell lineage commitment. The cessation of ThymoD transcription abolishes transcription‐mediated demethylation, recruiting looping factors such as the cohesin complex, CCCTC‐binding factor (CTCF), ultimately leading to the phenotype of severe combined immunodeficiency and T‐cell leukemia/lymphoma. In this review, we describe the functional role of RNA polymerase II‐mediated transcription at enhancers and in genome folding. We also highlight the involvement of faulty activation or suppression of enhancer transcription and enhancer‐promoter interaction in cancer development." @default.
- W2949628298 created "2019-06-27" @default.
- W2949628298 creator A5007113919 @default.
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- W2949628298 date "2019-07-10" @default.
- W2949628298 modified "2023-10-18" @default.
- W2949628298 title "Noncoding RNA transcription at enhancers and genome folding in cancer" @default.
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- W2949628298 doi "https://doi.org/10.1111/cas.14107" @default.
- W2949628298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6676135" @default.
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