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• W2949634824 abstract "Neurons in multiple brain regions fire trains of action potentials anticipating specific movements, but this preparatory activity has not been systematically compared across behavioral tasks. We compared preparatory activity in auditory and tactile delayed-response tasks in male mice. Skilled, directional licking was the motor output. The anterior lateral motor cortex (ALM) is necessary for motor planning in both tasks. Multiple features of ALM preparatory activity during the delay epoch were similar across tasks. First, most neurons showed direction-selective activity and spatially intermingled neurons were selective for either movement direction. Second, many cells showed mixed coding of sensory stimulus and licking direction, with a bias toward licking direction. Third, delay activity was monotonic and low-dimensional. Fourth, pairs of neurons with similar direction selectivity showed high spike-count correlations. Our study forms the foundation to analyze the neural circuit mechanisms underlying preparatory activity in a genetically tractable model organism.SIGNIFICANCE STATEMENT Short-term memories link events separated in time. Neurons in the frontal cortex fire trains of action potentials anticipating specific movements, often seconds before the movement. This preparatory activity has been observed in multiple brain regions, but has rarely been compared systematically across behavioral tasks in the same brain region. To identify common features of preparatory activity, we developed and compared preparatory activity in auditory and tactile delayed-response tasks in mice. The same cortical area is necessary for both tasks. Multiple features of preparatory activity, measured with high-density silicon probes, were similar across tasks. We find that preparatory activity is low-dimensional and monotonic. Our study forms a foundation for analyzing the circuit mechanisms underlying preparatory activity in a genetically tractable model organism." @default.
• W2949634824 created "2019-06-27" @default.
• W2949634824 creator A5001689486 @default.
• W2949634824 creator A5013286082 @default.
• W2949634824 creator A5065133138 @default.
• W2949634824 creator A5088944052 @default.
• W2949634824 date "2018-03-28" @default.
• W2949634824 modified "2023-10-17" @default.
• W2949634824 title "Low-Dimensional and Monotonic Preparatory Activity in Mouse Anterior Lateral Motor Cortex" @default.
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• W2949634824 doi "https://doi.org/10.1523/jneurosci.3152-17.2018" @default.
• W2949634824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596025" @default.
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• W2949634824 hasPublicationYear "2018" @default.
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