Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949649245> ?p ?o ?g. }
- W2949649245 endingPage "1151" @default.
- W2949649245 startingPage "1139" @default.
- W2949649245 abstract "Although clinically associated with the progression of multiple cancers, the biological function of p21‐activated kinase 5 (PAK5) in breast cancer remains largely unknown. Here, we reveal that the PAK5–aspartyl aminopeptidase (DNPEP)–ubiquitin‐specific protease 4 (USP4) axis is involved in breast cancer progression. We show that PAK5 interacts with and phosphorylates DNPEP at serine 119. Functionally, we demonstrate that DNPEP overexpression suppresses breast cancer cell proliferation and invasion and restricts breast cancer growth and metastasis in mice. Furthermore, we identify USP4 as a downstream target of the PAK5–DNPEP pathway; DNPEP mediates USP4 downregulation. Importantly, we verify that DNPEP expression is frequently downregulated in breast cancer tissues and is negatively correlated with PAK5 and USP4 expression. PAK5 decreases DNPEP abundance via the ubiquitin–proteasome pathway. Consistently, analyses of clinical breast cancer specimens revealed significantly increased PAK5 and USP4 levels and an association between higher PAK5 and USP4 expression and worse breast cancer patient survival. These findings suggest a pivotal role for PAK5‐elicited signaling in breast cancer progression." @default.
- W2949649245 created "2019-06-27" @default.
- W2949649245 creator A5000442440 @default.
- W2949649245 creator A5028012008 @default.
- W2949649245 creator A5032107505 @default.
- W2949649245 creator A5042032330 @default.
- W2949649245 creator A5042675351 @default.
- W2949649245 creator A5049761910 @default.
- W2949649245 creator A5056101043 @default.
- W2949649245 creator A5057538485 @default.
- W2949649245 creator A5061690935 @default.
- W2949649245 creator A5066927210 @default.
- W2949649245 creator A5086529957 @default.
- W2949649245 creator A5086779479 @default.
- W2949649245 creator A5088502720 @default.
- W2949649245 creator A5090965600 @default.
- W2949649245 date "2019-07-27" @default.
- W2949649245 modified "2023-10-17" @default.
- W2949649245 title "A PAK5–DNPEP–USP4 axis dictates breast cancer growth and metastasis" @default.
- W2949649245 cites W1563080703 @default.
- W2949649245 cites W1933679718 @default.
- W2949649245 cites W1963600040 @default.
- W2949649245 cites W1966353478 @default.
- W2949649245 cites W1970099989 @default.
- W2949649245 cites W1970402401 @default.
- W2949649245 cites W1980516263 @default.
- W2949649245 cites W1982474337 @default.
- W2949649245 cites W2018652550 @default.
- W2949649245 cites W2024795849 @default.
- W2949649245 cites W2029245460 @default.
- W2949649245 cites W2034979660 @default.
- W2949649245 cites W2050913482 @default.
- W2949649245 cites W2051190668 @default.
- W2949649245 cites W2052027903 @default.
- W2949649245 cites W2076583198 @default.
- W2949649245 cites W2080804646 @default.
- W2949649245 cites W2086468991 @default.
- W2949649245 cites W2107960969 @default.
- W2949649245 cites W2114388476 @default.
- W2949649245 cites W2117536783 @default.
- W2949649245 cites W2128647627 @default.
- W2949649245 cites W2130200307 @default.
- W2949649245 cites W2145325601 @default.
- W2949649245 cites W2150548551 @default.
- W2949649245 cites W2163997162 @default.
- W2949649245 cites W2166995947 @default.
- W2949649245 cites W2170158921 @default.
- W2949649245 cites W2219778402 @default.
- W2949649245 cites W2414372990 @default.
- W2949649245 cites W2495513541 @default.
- W2949649245 cites W2562685286 @default.
- W2949649245 cites W2570618306 @default.
- W2949649245 cites W2610421944 @default.
- W2949649245 cites W2610548862 @default.
- W2949649245 cites W2762481118 @default.
- W2949649245 cites W2765153420 @default.
- W2949649245 cites W2767201918 @default.
- W2949649245 cites W2791316031 @default.
- W2949649245 cites W2793760515 @default.
- W2949649245 cites W2885078288 @default.
- W2949649245 doi "https://doi.org/10.1002/ijc.32523" @default.
- W2949649245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31219614" @default.
- W2949649245 hasPublicationYear "2019" @default.
- W2949649245 type Work @default.
- W2949649245 sameAs 2949649245 @default.
- W2949649245 citedByCount "19" @default.
- W2949649245 countsByYear W29496492452020 @default.
- W2949649245 countsByYear W29496492452021 @default.
- W2949649245 countsByYear W29496492452022 @default.
- W2949649245 countsByYear W29496492452023 @default.
- W2949649245 crossrefType "journal-article" @default.
- W2949649245 hasAuthorship W2949649245A5000442440 @default.
- W2949649245 hasAuthorship W2949649245A5028012008 @default.
- W2949649245 hasAuthorship W2949649245A5032107505 @default.
- W2949649245 hasAuthorship W2949649245A5042032330 @default.
- W2949649245 hasAuthorship W2949649245A5042675351 @default.
- W2949649245 hasAuthorship W2949649245A5049761910 @default.
- W2949649245 hasAuthorship W2949649245A5056101043 @default.
- W2949649245 hasAuthorship W2949649245A5057538485 @default.
- W2949649245 hasAuthorship W2949649245A5061690935 @default.
- W2949649245 hasAuthorship W2949649245A5066927210 @default.
- W2949649245 hasAuthorship W2949649245A5086529957 @default.
- W2949649245 hasAuthorship W2949649245A5086779479 @default.
- W2949649245 hasAuthorship W2949649245A5088502720 @default.
- W2949649245 hasAuthorship W2949649245A5090965600 @default.
- W2949649245 hasBestOaLocation W29496492451 @default.
- W2949649245 hasConcept C104317684 @default.
- W2949649245 hasConcept C121608353 @default.
- W2949649245 hasConcept C126322002 @default.
- W2949649245 hasConcept C127561419 @default.
- W2949649245 hasConcept C2775930923 @default.
- W2949649245 hasConcept C2779013556 @default.
- W2949649245 hasConcept C502942594 @default.
- W2949649245 hasConcept C530470458 @default.
- W2949649245 hasConcept C55493867 @default.
- W2949649245 hasConcept C71924100 @default.
- W2949649245 hasConcept C86803240 @default.
- W2949649245 hasConceptScore W2949649245C104317684 @default.